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来自无环结构单元的2(1)-吡嗪酮：合成方法及进一步衍生化

2(1)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations.

作者信息

Riesco-Llach Gerard, Planas Marta, Feliu Lidia, Joule John A

机构信息

LIPPSO, Department of Chemistry, Universitat de Girona Maria Aurèlia Capmany 69 Girona 17003 Spain

The School of Chemistry, The University of Manchester Manchester M13 9PL UK

出版信息

RSC Adv. 2023 Jan 4;13(2):1162-1184. doi: 10.1039/d2ra07227k. eCollection 2023 Jan 3.

DOI:10.1039/d2ra07227k
PMID:36686909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9811941/
Abstract

Pyrazinones (2(1)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021.

摘要

吡嗪酮（2(1)-吡嗪酮）是一系列天然物质的组成成分，并且参与了大量生物活性分子的制备。此类化合物及其类似物的合成需要了解吡嗪酮的杂环性质，尤其是其环构建方法。本综述涉及从1905年的首个实例到2021年的最新实例，由无环前体，特别是α-氨基酸衍生单元合成吡嗪酮所开发的策略。

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