Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Molecules. 2023 Jul 15;28(14):5428. doi: 10.3390/molecules28145428.
ZrO nanoparticles have received substantially increased attention in every field of life owing to their wide range of applications. Zirconium oxide is a commercially economical, non-hazardous, and sustainable metal oxide having diversified potential applications. ZrO NPs play a vast role in the domain of medicine and pharmacy such as anticancer, antibacterial, and antioxidant agents and tissue engineering owing to their reliable curative biomedical applications. In this review article, we address all of the medical and biomedical applications of ZrO NPs prepared through various approaches in a critical way. ZrO is a bio-ceramic substance that has received increased attention in biomimetic scaffolds owing to its high mechanical strength, excellent biocompatibility, and high chemical stability. ZrO NPs have demonstrated potential anticancer activity against various cancer cells. ZrO-based nanomaterials have exhibited potential antibacterial activity against various bacterial strains and have also demonstrated excellent antioxidant activity. The ZrO nanocomposite also exhibits highly sensitive biosensing activity toward the sensing of glucose and other biological species.
ZrO 纳米粒子由于其广泛的应用而在生活的各个领域受到了极大的关注。氧化锆是一种商业经济、无危险和可持续的金属氧化物，具有多样化的潜在应用。ZrO NPs 在医学和药学领域发挥着重要作用，如抗癌、抗菌和抗氧化剂以及组织工程，因为它们具有可靠的治疗生物医学应用。在这篇综述文章中，我们以批判性的方式讨论了通过各种方法制备的 ZrO NPs 在所有医学和生物医学应用中的作用。ZrO 是一种生物陶瓷物质，由于其高强度、优异的生物相容性和高化学稳定性，在仿生支架中受到了越来越多的关注。ZrO NPs 对各种癌细胞表现出潜在的抗癌活性。基于 ZrO 的纳米材料对各种细菌菌株表现出潜在的抗菌活性，并且还表现出优异的抗氧化活性。ZrO 纳米复合材料对葡萄糖和其他生物物种的传感也表现出高度敏感的生物传感活性。
