Santra Dipannita, Banerjee Amrita, De Subrata Kr, Thatoi Hrudayanath, Maiti Smarajit
Department of Biochemistry and Biotechnology, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Midnapore, India.
Department of Zoology, Vidyasagar University, Midnapore, 721102 India.
Comp Clin Path. 2023;32(2):179-189. doi: 10.1007/s00580-023-03434-9. Epub 2023 Jan 17.
In the last 3 years of the pandemic situation, SARS-CoV-2 caused a significant number of deaths. Infection rates for symptomatic and asymptomatic patients are higher than that for death. Eventually, researchers explored that the major deaths are attributed to several comorbidity factors. The confounding factors and gender-associated infection/death rate are observed globally. This suggests that SARS-CoV-2 selects the human system recognizing the internal comorbid environment. This article explored the influences of hypertension, diabetes, cardiovascular, and renovascular disorders in COVID-19 severity and mortality. Brief mechanistic layouts have been presented here, indicating some of the comorbidity as the critical determinant in the COVID-19 pathogenesis and related mortality.
在疫情形势的过去3年里，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）导致了大量死亡。有症状和无症状患者的感染率高于死亡率。最终，研究人员发现主要死亡归因于几个合并症因素。全球都观察到了混杂因素以及与性别相关的感染/死亡率。这表明SARS-CoV-2选择了识别内部合并症环境的人体系统。本文探讨了高血压、糖尿病、心血管和肾血管疾病对新型冠状病毒肺炎（COVID-19）严重程度和死亡率的影响。这里呈现了简要的机制布局，表明一些合并症是COVID-19发病机制及相关死亡率的关键决定因素。
