Chen Tianyu, Zhao Xiaoying, Weng Yunxuan
College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China.
Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing, China.
Front Chem. 2023 Jan 6;10:1107620. doi: 10.3389/fchem.2022.1107620. eCollection 2022.
The surface morphology and topography of cell culture substrates play an important role in cell proliferation and growth. Regulation of the surface microstructure allows the development of tissue culture media suitable for different cells. Polylactic acid (PLA) is a biobased and biodegradable (under defined conditions) polymer with low immunogenicity, non-toxicity, and good mechanical properties, which have facilitated their pharmaceutical and biomedical applications. This review summarizes recent advances in the synthesis and self-assembly of surface microstructure based on PLA materials and discusses their biomedical applications such as cell culturing and tissue engineering.
细胞培养底物的表面形态和形貌在细胞增殖和生长中起着重要作用。对表面微观结构的调控有助于开发适用于不同细胞的组织培养基。聚乳酸（PLA）是一种生物基且可（在特定条件下）生物降解的聚合物，具有低免疫原性、无毒性和良好的机械性能，这些特性促进了其在制药和生物医学领域的应用。本文综述了基于PLA材料的表面微观结构合成与自组装的最新进展，并讨论了它们在细胞培养和组织工程等生物医学领域的应用。
