Chen Xin, Li Honghai, Lu Weipeng, Guo Yanchuan
Key Laboratory of Photochemical Conversion and Optoelectronic Material, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Nanomaterials (Basel). 2021 May 17;11(5):1316. doi: 10.3390/nano11051316.
The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against . Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems.
药物突释现象是药物递送系统领域的主要问题，因为这意味着无法实现良好的治疗效果。通过静电纺丝技术制备的纳米纤维具有大的比表面积、高孔隙率以及易于控制的形态。它们正被视为实现药物持续释放的潜在载体。在本文中，我们采用同轴静电纺丝技术和非溶剂诱导相分离法制备了聚己内酯（PCL）/聚乳酸（PLA）核壳多孔载药纳米纤维。将一种抗菌剂罗红霉素（ROX）包裹在核层中。通过扫描电子显微镜（SEM）、衰减全反射傅里叶变换红外（ATR - FTIR）光谱、差示扫描量热法（DSC）和热重分析（TGA）对所得纳米纤维的形态、组成和热性能进行了表征。除此之外，还研究了体外药物释放曲线；结果表明，制备的两种不同孔径的同轴多孔纳米纤维在前30分钟的释放率分别为30.10±3.51%和35.04±1.98%，14天后分别达到92.66±3.13%和88.94±1.58%。与同轴无孔纳米纤维以及通过单轴静电纺丝制备的有孔或无孔纳米纤维相比，制备的同轴多孔纳米纤维显示出突释得到缓解，疏水性药物的溶解速率增加。进一步的抗菌活性表明，两种不同孔径的同轴纳米纤维的抑菌圈直径分别为1.70±0.10厘米和1.73±0.23厘米，对……表现出良好的抗菌效果。因此，制备的具有同轴多孔结构的纳米纤维可作为很有前景的药物递送系统。
