Xiao Ning, Xu Xingli, Ma Zhiyue, Yu Xiaoxu, Feng Yong, Li Bilan, Liu Yuping, He Gang, Fan Jiangang, Li Bin, Zhao Xiaolong
Department of Health Management Center and Institute of Health Management, Sichuan Provincial People's Hospital, Chengdu, China.
Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Behav Neurosci. 2023 Jan 4;16:867650. doi: 10.3389/fnbeh.2022.867650. eCollection 2022.
Many countries have currently relied on various types of vaccines for the public to control the coronavirus disease 2019 (COVID-19) pandemic. The adverse reactions (ARs) after vaccination may affect vaccination coverage and confidence. However, whether sleep quality was associated with ARs after vaccination remains unclear.
We designed a longitudinal paired study within a hospital setting. We collected data about the side effects within 7 days after two doses of scheduled vaccination among healthcare workers (HCWs). All HCWs were asked to complete a sleep survey indexed by the Pittsburgh Sleep Quality Index (PSQI) before vaccination and after a 1-month follow-up. Then, we explored the relationship between sleep quality before or after vaccination and the occurrence of ARs.
A total of 345 HCWs were recruited to receive COVID-19 vaccination. The sleep quality became worse after vaccination. All local and systemic reactions were mild or moderate in severity (32.46%), and no serious adverse event was reported. Binary logistic regression showed participants with poor sleep quality (PSQI > 5) than good sleep quality (PSQI ≤ 5) before the two doses of vaccination, respectively, exhibited 1.515 and 1.107 times risk of ARs after each vaccination (both < 0.001).
There is an apparently complex bidirectional relationship between sleep quality and COVID-19 vaccination adverse effects. Poor sleep quality significantly increases the risk of mild ARs after vaccination, while vaccination may cause a temporary decline in sleep quality.
目前许多国家依靠各类疫苗供公众使用，以控制2019冠状病毒病（COVID-19）大流行。接种疫苗后的不良反应可能会影响疫苗接种覆盖率和信心。然而，睡眠质量与接种疫苗后的不良反应之间是否存在关联仍不清楚。
我们在医院环境中设计了一项纵向配对研究。我们收集了医护人员在接种两剂计划疫苗后7天内的副作用数据。所有医护人员在接种疫苗前和1个月随访后均被要求完成一项以匹兹堡睡眠质量指数（PSQI）为指标的睡眠调查。然后，我们探讨了接种疫苗前后的睡眠质量与不良反应发生之间的关系。
共招募了345名医护人员接种COVID-19疫苗。接种疫苗后睡眠质量变差。所有局部和全身反应的严重程度均为轻度或中度（32.46%），未报告严重不良事件。二元逻辑回归显示，在接种两剂疫苗前，睡眠质量差（PSQI>5）的参与者比睡眠质量好（PSQI≤5）的参与者在每次接种后出现不良反应的风险分别高1.515倍和1.107倍（均<0.001）。
睡眠质量与COVID-19疫苗接种不良反应之间存在明显复杂的双向关系。睡眠质量差会显著增加接种疫苗后出现轻度不良反应的风险，而接种疫苗可能会导致睡眠质量暂时下降。
