Okuyama Kohei, Yanamoto Souichi
Department of Periodontics & Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, Michigan.
University of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Cancer Prev Res (Phila). 2023 Apr 3;16(4):199-209. doi: 10.1158/1940-6207.CAPR-22-0511.
Several periodontitis-associated species induce genes related to cell proliferation, cell-cycle progression, apoptosis, intracellular transport, immune and inflammatory responses, carcinogenesis, and cancer progression. Here, we reviewed studies showing strong associations between gingival squamous cell carcinoma (GSCC) and three periodontitis-related oral bacteria (Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia) in the microenvironment. These bacteria produce cytoplasmic lipopolysaccharide (LPS) and secrete cytokines and molecules related to carcinogenesis, tumor progression, and metastasis and metastasis. In GSCC, LPS levels are substantially elevated and assessable by functional analysis. Polymicrobial infections can synergistically induce inflammation and significantly upregulate proinflammatory molecules (e.g., IL1β, IL8, and TNFα) that promote carcinogenesis. This review can facilitate the identification of novel targets for treating and preventing GSCC, which is potentially associated with periodontal pathogen.
几种与牙周炎相关的菌种可诱导与细胞增殖、细胞周期进程、细胞凋亡、细胞内运输、免疫和炎症反应、致癌作用及癌症进展相关的基因。在此，我们综述了一些研究，这些研究表明牙龈鳞状细胞癌（GSCC）与微环境中三种与牙周炎相关的口腔细菌（牙龈卟啉单胞菌、具核梭杆菌和中间普氏菌）之间存在密切关联。这些细菌产生细胞质脂多糖（LPS），并分泌与致癌作用、肿瘤进展和转移相关的细胞因子和分子。在GSCC中，LPS水平显著升高，可通过功能分析进行评估。多微生物感染可协同诱导炎症，并显著上调促进致癌作用的促炎分子（如IL1β、IL8和TNFα）。本综述有助于确定治疗和预防GSCC的新靶点，GSCC可能与牙周病原体有关。
