炎症性肠病患者的戊聚糖多硫酸盐相关性发育不良：病例系列研究。
Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series.
机构信息
Oregon Health & Science University, Department of Medicine, Division of Gastroenterology & Hepatology, Portland, Oregon, USA.
Stanford University, Department of Medicine, Division of Gastroenterology & Hepatology, Stanford, California, USA.
出版信息
Am J Gastroenterol. 2023 May 1;118(5):905-908. doi: 10.14309/ajg.0000000000002137. Epub 2022 Dec 23.
INTRODUCTION
This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia.
METHODS
We searched electronic medical records to identify patients with IBD using PPS.
RESULTS
Ten of 30 identified patients (33.3%) had colonic dysplasia. Six of them (60%) underwent colectomy for endoscopically unresectable dysplasia. Three (10%) discontinued PPS, each with an apparent benefit.
DISCUSSION
Patients with IBD at 2 institutions who had taken PPS had high rates of colonic dysplasia leading to surgery. Patients who stopped PPS showed improvement in their colitis. PPS may play a causal role in the development of colitis and dysplasia.
简介
本研究评估了戊聚糖多硫酸酯（PPS）与炎症性肠病（IBD）或异型增生的潜在关联。
方法
我们通过 PPS 搜索电子病历以识别患有 IBD 的患者。
结果
在 30 名确定的患者中，有 10 名（33.3%）患有结肠异型增生。其中 6 名（60%）因内镜下不可切除的异型增生而行结肠切除术。3 名（10%）停止使用 PPS，且每位患者的结肠炎均有明显改善。
讨论
在 2 家机构中，接受 PPS 治疗的 IBD 患者结肠异型增生发生率较高，导致手术。停止使用 PPS 的患者其结肠炎得到改善。PPS 可能在结肠炎和异型增生的发展中起因果作用。
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