光学相干断层扫描血管造影术观察正常人眼中心凹无血管区。

Foveal avascular zone in normal human eyes by optical coherence tomography angiography.

机构信息

Department of ophthalmology, Chifeng Chaoju Eye Hospital, Chifeng, 024000, China.

Department of ophthalmology, Datong Chaoju Ankang Eye Hospital, Datong, 037006, China.

出版信息

Photodiagnosis Photodyn Ther. 2023 Jun;42:103303. doi: 10.1016/j.pdpdt.2023.103303. Epub 2023 Jan 21.

DOI:10.1016/j.pdpdt.2023.103303

PMID:36690195

Abstract

OBJECTIVE

To analyze the influence factors of the area of superficial plexus foveal avascular zone (FAZ) and related indexes of fovea measured with optical coherence tomography angiography (OCT-A) in normal subjects.

METHODS

This was a cross-sectional study from November 2020 to May 2021 in the Inner Mongolia Autonomous Region, China. Each subject received related eye examination. The correlation between all the factors and superficial plexus FAZ were analyzed under univariable and multivariable linear regression analysis.

RESULTS

Finally, 239 subjects with sufficient data were recruited in the study, including 108 males and 131 females, aged 27.41±4.63 years. The area of superficial plexus FAZ was 0.33±0.16 mm. In the univariate regression, gender (β = 41.702, 95%CI: 9.152 to 74.253, P = 0.012), drinking (β = -66.074, 95%CI: -99.197 to -32.951, P = 0.001) and axial length (β = -15.874, 95%CI: -29.562 to -2.185, P = 0.023) were associated with superficial plexus FAZ area. In multivariate regression analysis results, drinking (β = -42.410, 95%CI = -79.388 to -5.432, P = 0.025) was significantly correlated with superficial plexus FAZ area.

CONCLUSION

The area of superficial plexus FAZ was not affected by age, gender, systematical and biochemical indicators, but related to the status of drinking.

摘要

目的

分析正常人群中光学相干断层扫描血管造影（OCT-A）测量的浅层神经纤维丛凹面无血管区（FAZ）面积及其相关指标的影响因素。

方法

这是 2020 年 11 月至 2021 年 5 月在中国内蒙古自治区进行的一项横断面研究。每位受试者均接受了相关的眼部检查。在单变量和多变量线性回归分析下，分析所有因素与浅层神经纤维丛 FAZ 的相关性。

结果

最终，研究共纳入 239 例数据充足的受试者，其中男性 108 例，女性 131 例，年龄 27.41±4.63 岁。浅层神经纤维丛 FAZ 面积为 0.33±0.16mm。在单变量回归中，性别（β=41.702，95%CI：9.152 至 74.253，P=0.012）、饮酒（β=-66.074，95%CI：-99.197 至-32.951，P=0.001）和眼轴长度（β=-15.874，95%CI：-29.562 至-2.185，P=0.023）与浅层神经纤维丛 FAZ 面积相关。在多变量回归分析结果中，饮酒（β=-42.410，95%CI=-79.388 至-5.432，P=0.025）与浅层神经纤维丛 FAZ 面积显著相关。