饮食磷摄入量与新发高血压之间的U型关联：一项中国全国性队列研究
A U-shaped association between dietary phosphorus intake and new-onset hypertension: a nationwide cohort study in China.
作者信息
Wu Qimeng, Ye Ziliang, Zhou Chun, Liu Mengyi, Zhang Yuanyuan, Zhang Zhuxian, He Panpan, Li Rui, Li Huan, Yang Sisi, Zhang Yanjun, Jiang Jianping, Nie Jing, Liu Chengzhang, Qin Xianhui
机构信息
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China; Institute of Biomedicine, Anhui Medical University, Hefei, 230032, China.
出版信息
Am Heart J. 2023 May;259:21-29. doi: 10.1016/j.ahj.2023.01.013. Epub 2023 Jan 20.
BACKGROUND
The association between dietary phosphorus intake and the risk of hypertension remains uncertain. We aimed to investigate the relation of dietary phosphorus intake with new-onset hypertension among Chinese adults.
METHODS
A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. New-onset hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or diagnosed by a physician or under antihypertensive treatment during the follow-up.
RESULTS
During a median follow-up of 6.1 years, 4,269 participants developed new-onset hypertension. Overall, the association between dietary phosphorus intake and new-onset hypertension followed a U-shape (P for nonlinearity<.001). Consistently, when dietary phosphorus intake was assessed as quintiles, compared with those in the 3rd to 4th quintiles (912.0-<1089.5 mg/d), a significantly higher risk of new-onset hypertension was found in participants in the 1st to 2nd quintiles (<912.0 mg/d: HR, 1.23; 95% CI, 1.14-1.33), and the fifth quintile (≥1089.5 mg/d: HR, 1.21; 95% CI, 1.10-1.33).
CONCLUSION
There was a U-shaped association between dietary phosphorus intake and new-onset hypertension in general Chinese adults.
背景
膳食磷摄入量与高血压风险之间的关联仍不确定。我们旨在研究中国成年人膳食磷摄入量与新发高血压之间的关系。
方法
纳入了中国健康与营养调查（CHNS）中共有12177名基线时无高血压的参与者。通过连续3天的24小时膳食回顾结合家庭食物清单来测量膳食摄入量。新发高血压定义为收缩压≥140 mmHg或舒张压≥90 mmHg，或在随访期间由医生诊断或正在接受抗高血压治疗。
结果
在中位随访6.1年期间，4269名参与者出现了新发高血压。总体而言，膳食磷摄入量与新发高血压之间的关联呈U形（非线性P<.001）。同样，当将膳食磷摄入量评估为五分位数时，与第3至第4五分位数（912.0-<1089.5 mg/d）的参与者相比，第1至第2五分位数（<912.0 mg/d：HR，1.23；95%CI，1.14-1.33）和第5五分位数（≥1089.5 mg/d：HR，1.21；95%CI，1.10-1.33）的参与者新发高血压风险显著更高。
结论
一般中国成年人的膳食磷摄入量与新发高血压之间存在U形关联。
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