Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou, 510515, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Hypertens Res. 2023 May;46(5):1267-1275. doi: 10.1038/s41440-022-01163-0. Epub 2023 Jan 6.
The association between dietary vitamin E intake and the risk of new-onset hypertension remains unknown. We aimed to evaluate the prospective relationship of dietary vitamin E intake with new-onset hypertension in the general Chinese population. A total of 12,177 adults without hypertension at baseline were enrolled from the China Health and Nutrition Survey. Dietary intake was measured by 3 consecutive 24 h dietary recalls at the individual level in combination with a weighing inventory taken over the same 3 days at the household level. The study outcome was new-onset hypertension, defined as a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, a diagnosis by a physician, or the use of antihypertensive treatment during follow-up. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary vitamin E intake and new-onset hypertension followed a reverse J-shaped curve (P for nonlinearity <0.001). Accordingly, when dietary vitamin E intake was assessed by quintiles, significantly higher risks of new-onset hypertension were found among participants in the first quintile (<18.75 mg/d: adjusted HR, 1.40; 95% CI, 1.29-1.52) and the fifth quintile (≥40.53 mg/d: adjusted HR, 1.18; 95% CI, 1.09-1.29) compared with those in the second-fourth quintiles (18.75 to <40.53 mg/d). Further adjustments for vitamin A, riboflavin, niacin, vitamin C, zinc, copper, and selenium intake or the intake of vegetables, fruits, legumes, grains, nuts, and vegetable oils did not substantially change the results. In conclusion, there was a reverse J-shaped association between dietary vitamin E intake and new-onset hypertension in general Chinese adults.
膳食维生素 E 摄入与新发高血压风险之间的关系尚不清楚。我们旨在评估一般中国人群中膳食维生素 E 摄入与新发高血压之间的前瞻性关系。共有 12177 名基线时无高血压的成年人从中国健康与营养调查中入选。通过个体层面的连续 3 天 24 小时膳食回顾和家庭层面的相同 3 天称重调查，测量膳食摄入量。研究结局为新发高血压，定义为收缩压≥140mmHg 和/或舒张压≥90mmHg，由医生诊断，或在随访期间使用抗高血压治疗。在中位随访 6.1 年期间，4269 名参与者发生新发高血压。总的来说，膳食维生素 E 摄入与新发高血压之间的关系呈反向 J 形曲线（非线性 P<0.001）。因此，当按五分位数评估膳食维生素 E 摄入时，与第二至第四五分位组（18.75 至<40.53mg/d：调整后 HR，1.40；95%CI，1.29-1.52）相比，第一五分位组（<18.75mg/d：调整后 HR，1.40；95%CI，1.29-1.52）和第五五分位组（≥40.53mg/d：调整后 HR，1.18；95%CI，1.09-1.29）发生新发高血压的风险显著更高。进一步调整维生素 A、核黄素、烟酸、维生素 C、锌、铜和硒摄入或蔬菜、水果、豆类、谷物、坚果和植物油摄入并没有显著改变结果。总之，一般中国成年人中膳食维生素 E 摄入与新发高血压之间呈反向 J 形关联。
