溃疡性结肠炎缓解期患者焦虑与生活质量的相关性。
The interrelation between anxiety and quality of life among patients with ulcerative colitis in remission.
机构信息
Neurology and Psychiatry Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia Sección XVI, Tlalpan, CP 14080 Mexico City, Mexico.
Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Belisario Domínguez Secc 16, Tlalpan, 14080 Mexico City, Mexico.
出版信息
Gastroenterol Hepatol. 2023 Dec;46(10):747-753. doi: 10.1016/j.gastrohep.2023.01.003. Epub 2023 Jan 20.
OBJECTIVE
To determine if anxiety and depression are associated with a lower QoL in patients with UC in remission.
PATIENTS AND METHODS
We included consecutive patients with a previously confirmed diagnosis of UC in remission for at least 12 months and who answered complete questionnaires: IBDQ-32, HAD. Clinical and sociodemographic characteristics were obtained. We performed non-parametric tests, and correlations between HADS and IBDQ-32 were analyzed using Spearman's correlation coefficient (r). A p-value of less than 0.05 was considered significant.
RESULTS
Among 124 patients, 65% were men, with a median evolution of UC of 10 years (IQR: 5-79 years). Prevalence for anxiety was 15.3% and 2.4% for depression. Global QoL was 192 (IQR: 175-208). Lower QoL was associated with anxiety (p=0.002) and depression (p=0.013). Depression represented lower QoL at the digestive level than no depression (p=0.04). Anxiety negatively correlated with QoL (r=-0.54; p<0.001).
CONCLUSIONS
Anxiety is frequent in patients with UC in remission; therefore, timely diagnosis and treatment must be implemented to improve QoL.
目的
确定在缓解期的 UC 患者中，焦虑和抑郁是否与较低的生活质量相关。
患者和方法
我们纳入了此前确诊为缓解期 UC 且缓解期至少 12 个月且回答了完整问卷的连续患者：IBDQ-32、HAD。获取了临床和社会人口学特征。我们进行了非参数检验，并使用 Spearman 相关系数（r）分析了 HAD 和 IBDQ-32 之间的相关性。p 值小于 0.05 被认为具有统计学意义。
结果
在 124 名患者中，65%为男性，UC 的中位病程为 10 年（IQR：5-79 年）。焦虑的患病率为 15.3%，抑郁的患病率为 2.4%。总体生活质量为 192（IQR：175-208）。生活质量较低与焦虑（p=0.002）和抑郁（p=0.013）相关。与无抑郁的患者相比，抑郁患者的消化相关生活质量更低（p=0.04）。焦虑与生活质量呈负相关（r=-0.54；p<0.001）。
结论
在缓解期的 UC 患者中，焦虑很常见；因此，必须及时进行诊断和治疗以改善生活质量。
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