巴尔特 PLA（BaltPLA）对感染登革热病毒的细胞活力的影响，巴尔特 PLA 是矛头蝮蛇蛇毒中的一种磷脂酶 A。
Effect of BaltPLA, a phospholipase A from Bothrops alternatus snake venom, on the viability of cells infected with dengue virus.
机构信息
Biotechnology Institute, Federal University of Catalão (UFCAT), Catalão, Goiás, Brazil.
Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
出版信息
Toxicol In Vitro. 2023 Apr;88:105562. doi: 10.1016/j.tiv.2023.105562. Epub 2023 Jan 20.
Dengue fever is considered a major public health problem in tropical and subtropical regions. Our study analyzed the effect of BaltPLA a phospholipase A from Bothrops alternatus snake venom, on the viability of cells infected with Dengue virus. In presence of BaltPLA, the viability of infected cells increased significantly in virucidal, post-treatment, and adsorption assays. Although preliminary these results reveal the need for further studies to investigated whether BaltPLA has antiviral activity against Dengue virus.
登革热被认为是热带和亚热带地区的主要公共卫生问题。我们的研究分析了来自矛头蝮蛇（Bothrops alternatus）蛇毒的磷脂酶 A（BaltPLA）对感染登革病毒的细胞活力的影响。在 BaltPLA 的存在下，感染细胞在病毒杀灭、后处理和吸附测定中的活力显著增加。尽管这些结果是初步的，但它们表明需要进一步研究，以研究 BaltPLA 是否对登革病毒具有抗病毒活性。
Zotero 插件