School of Public Health, Shenyang Medical College, 146 Huanghe North Street, Shenyang, 110034, China.
Neurol Sci. 2023 Jun;44(6):2017-2024. doi: 10.1007/s10072-023-06620-3. Epub 2023 Jan 24.
To explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson's disease dementia (PDD), a meta-analysis was conducted.
The relevant studies were identified by searching PubMed, Embase, Web of Science, and Cochrane Collaboration Database up to May 2022. Pooled analysis, sensitivity analysis, and publication bias examination were all conducted. All analyses were performed by using STATA 16.
Twelve studies with a total of 2097 subjects were included. The pooled analysis showed that UA levels were not associated with VaD (WMD = - 10.99 μmol/L, 95% CI (- 48.05, 26.07), P = 0.561) but were associated with PDD (WMD = - 25.22 μmol/L, 95% CI (- 43.47, - 6.97), P = 0.007). The statistical stability and reliability were evaluated using sensitivity analysis and publication bias outcomes.
UA levels are associated with PDD but not with VaD. This study will help to strengthen our knowledge of the pathophysiologies of VaD and PDD, and promote the development of prevention and treatment strategies.
探讨尿酸（UA）水平与血管性痴呆（VaD）和帕金森病痴呆（PDD）的关系，进行了一项荟萃分析。
通过检索 PubMed、Embase、Web of Science 和 Cochrane 协作数据库，截至 2022 年 5 月，确定了相关研究。进行了汇总分析、敏感性分析和发表偏倚检验。所有分析均使用 STATA 16 进行。
纳入了 12 项研究，共计 2097 名受试者。汇总分析显示，UA 水平与 VaD 无关（WMD=-10.99 μmol/L，95%CI（-48.05，26.07），P=0.561），但与 PDD 相关（WMD=-25.22 μmol/L，95%CI（-43.47，-6.97），P=0.007）。使用敏感性分析和发表偏倚结果评估了统计稳定性和可靠性。
UA 水平与 PDD 相关，但与 VaD 无关。本研究将有助于加强我们对 VaD 和 PDD 病理生理学的认识，并促进预防和治疗策略的发展。
