Institute for Clinical Biochemistry and Immunology University of Sarajevo Clinics Center, Sarajevo, Bosnia and Herzegovina.
Faculty of Health Studies, University of Sarajevo, Bosnia and Herzegovina.
Med Arch. 2020 Apr;74(2):95-99. doi: 10.5455/medarh.2020.74.95-99.
Significance of serum uric acid (UA) in cerebrovascular disease still remains controversial. UA is most abundant natural antioxidant in human plasma. Its antioxidant properties might protect against free radical damage, thereby reducing the risk of oxidative stress-related cognitive impairment and dementia.
In our investigation, we determine the level of UA in 100 male patients diagnosed with the first ischemic brain stroke (blood samples were collected during the acute phase and post-acute phase), 100 male patients diagnosed with vascular dementia and 100 male healthy volunteers (control group).
UA was determined using DIMENSION LxR automatic analyzer. Measurement of UA concentration was based on an enzymatic method (range 208-428 μmol/L).
The prevalence of hyperuricemia among ischemic stroke and vascular dementia patients was 30% and 8%, respectively. Serum UA concentration was higher 7 and 14 days after the stroke compared to the acute phase (24-48 hours after hospitalization) and these concentrations were significantly higher than those measured in the control group. UA levels measured at 24-48 hours after the first symptoms of ischemic stroke were strongly correlated with those measured after 7 days of treatment (r = 0.79, p = 0.001) or after 14 days (r = 0.839, p = 0.0049). No significant differences were found between ischemic stroke and vascular dementia groups.
UA concentrations were higher in ischemic stroke and vascular dementia groups than in controls. UA increase may reflect vascular atherosclerosis and tissue hypoxia. UA monitoring in patients with cerebrovascular disease is essential, because UA is more harmful than protective.
血清尿酸（UA）在脑血管病中的意义仍存在争议。UA 是人类血浆中含量最丰富的天然抗氧化剂。其抗氧化特性可能有助于防止自由基损伤，从而降低与氧化应激相关的认知障碍和痴呆的风险。
在我们的研究中，我们测定了 100 例首次缺血性脑中风（在急性期和亚急性期采集血样）、100 例血管性痴呆男性患者和 100 例男性健康志愿者（对照组）的 UA 水平。
使用 DIMENSION LxR 自动分析仪测定 UA。UA 浓度的测定基于酶法（范围 208-428 μmol/L）。
缺血性中风和血管性痴呆患者的高尿酸血症患病率分别为 30%和 8%。中风后 7 天和 14 天，血清 UA 浓度高于急性期（住院后 24-48 小时），且明显高于对照组。缺血性中风首次症状发作后 24-48 小时测量的 UA 水平与治疗后 7 天（r = 0.79，p = 0.001）或 14 天（r = 0.839，p = 0.0049）测量的 UA 水平密切相关。缺血性中风组和血管性痴呆组之间无显著差异。
缺血性中风和血管性痴呆组的 UA 浓度高于对照组。UA 升高可能反映血管动脉粥样硬化和组织缺氧。对脑血管病患者进行 UA 监测至关重要，因为 UA 的危害性大于保护性。
