Center of Excellence in Genomics and Precision Dentistry, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.
Geriatric Dentistry and Special Patients Care Program, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
BMC Oral Health. 2023 Jan 23;23(1):37. doi: 10.1186/s12903-023-02753-1.
Sex dimorphism has been implicated in oral health differences and the pathogenesis of oral diseases, such as tooth agenesis, periodontal disease, dental caries, and tooth loss. Tooth agenesis (TA) is one of the most common developmental anomalies in humans, and its prevalence and patterns are different across ethnic groups. The aim of this study was to investigate the phenotypes and sex-associated patterns of nonsyndromic tooth agenesis (TA) in Thai dental patients.
One thousand ninety panoramic radiographs were examined. One hundred and one subjects (37 males, 64 females, 15-20 years-old) with nonsyndromic TA were evaluated. Differences in TA prevalence between groups were analyzed using the chi-square or Fisher exact test.
The TA prevalence, excluding third molars, was 9.3% and more frequently found in the mandible compared with the maxilla. The maxilla demonstrated a higher prevalence of first premolar agenesis than the mandible (P = 0.012), while the mandible had a higher prevalence of second premolar agenesis than the maxilla (P = 0.031). There were significantly more males missing one tooth than females, however, there were more females missing two or more teeth than males (P = 0.042). A missing maxillary left lateral incisor was significantly more frequent in males (P = 0.019), while a missing mandibular right lateral incisor was more frequent in females (P = 0.025). In females, the pattern of two mandibular lateral incisors agenesis was the most common and significantly present in females more than males (P = 0.015). In contrast, the pattern of one mandibular left lateral incisor agenesis was only observed in males and significantly found in males more than females (P = 0.047).
We demonstrate sex-associated differences in nonsyndromic tooth agenesis. The prevalence of single tooth agenesis was higher in males, while that of two or more teeth agenesis was higher in females. We found different patterns of lateral incisor agenesis between males and females.
性别二态性与口腔健康差异和口腔疾病的发病机制有关，例如牙齿缺失、牙周病、龋齿和牙齿脱落。牙齿缺失（TA）是人类最常见的发育异常之一，其患病率和模式在不同种族之间有所不同。本研究旨在调查泰国牙科患者中非综合征性牙齿缺失（TA）的表型和与性别相关的模式。
检查了 1090 张全景片。评估了 101 名（37 名男性，64 名女性，15-20 岁）非综合征性 TA 患者。使用卡方或 Fisher 精确检验分析组间 TA 患病率的差异。
不包括第三磨牙的 TA 患病率为 9.3%，下颌较上颌更常见。上颌第一前磨牙缺失的患病率高于下颌（P=0.012），而下颌第二前磨牙缺失的患病率高于上颌（P=0.031）。缺失一颗牙的男性明显多于女性，但缺失两颗或更多牙的女性明显多于男性（P=0.042）。男性缺失上颌左侧侧切牙的频率明显更高（P=0.019），而女性缺失下颌右侧侧切牙的频率更高（P=0.025）。在女性中，下颌双侧侧切牙缺失的模式最为常见，明显多于男性（P=0.015）。相反，下颌左侧侧切牙缺失的模式仅见于男性，且明显多于女性（P=0.047）。
我们证明了非综合征性牙齿缺失与性别相关的差异。单颗牙齿缺失在男性中更为常见，而两颗或更多牙齿缺失在女性中更为常见。我们发现了男性和女性之间侧切牙缺失模式的不同。
