Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Gastroenterology, Haining Branch of the First Affiliated Hospital, Zhejiang University School of Medicine, Haining, China
BMJ Open. 2022 Jun 3;12(6):e048574. doi: 10.1136/bmjopen-2020-048574.
Hyperuricaemia is closely related to metabolic diseases and is receiving increasing attention from all over the world. This study aimed to investigate the prevalence and factors associated with hyperuricaemia in non-obese Chinese population.
Retrospective cross-sectional study.
A large general hospital that can provide health check-ups in Hangzhou, China.
A total of 5731 apparently healthy Chinese adults (2349 men and 3382 women) who took their health check-ups during the year of 2019.
(1) those with body mass index ≥24 kg/m; (2) those with incomplete anthropometric and biochemical data; (3) those with a history of malignancy and (4) those under urate-lowering treatment.
The prevalence and factors associated with hyperuricaemia in non-obese Chinese adults.
Of the 5731 non-obese subjects enrolled, 538 (9.4%) were identified as having hyperuricaemia, specifically 16.3% in men and 4.6% in women. The prevalence of hyperuricaemia markedly increased in women aged above 50 years. The prevalence of hyperuricaemia was significantly higher in metabolically unhealthy participants with normal weight than in metabolically healthy participants with normal weight. Participants with hyperuricaemia showed a higher prevalence of metabolic syndrome and fatty liver disease than participants with normouraemia. Age, waist circumference, estimated glomerular filtration rate, blood urea nitrogen, excessive drinking and fatty liver were associated with hyperuricaemia in both genders.
The prevalence of hyperuricaemia was 9.4% in non-obese Chinese adults. Non-obese participants with hyperuricaemia also showed multiple metabolic disorders. We suggest that clinicians pay attention to serum uric acid level in non-obese patients.
高尿酸血症与代谢性疾病密切相关，正受到全世界越来越多的关注。本研究旨在调查非肥胖中国人群中高尿酸血症的患病率及相关因素。
回顾性横断面研究。
中国杭州一家大型综合医院，可提供健康体检。
共有 5731 名看似健康的中国成年人（2349 名男性和 3382 名女性）在 2019 年进行了健康体检。
（1）身体质量指数≥24kg/m²；（2）存在不完全的人体测量学和生化数据；（3）有恶性肿瘤病史；（4）正在进行降尿酸治疗。
非肥胖中国成年人高尿酸血症的患病率及相关因素。
在纳入的 5731 名非肥胖受试者中，538 名（9.4%）被诊断为高尿酸血症，其中男性占 16.3%，女性占 4.6%。女性年龄超过 50 岁后，高尿酸血症的患病率明显增加。与代谢健康的正常体重参与者相比，代谢不健康的正常体重参与者中高尿酸血症的患病率显著更高。高尿酸血症组的代谢综合征和脂肪肝患病率明显高于正常尿酸血症组。年龄、腰围、估算肾小球滤过率、血尿素氮、过量饮酒和脂肪肝在两性中均与高尿酸血症相关。
非肥胖中国成年人高尿酸血症的患病率为 9.4%。非肥胖高尿酸血症患者也存在多种代谢紊乱。我们建议临床医生关注非肥胖患者的血尿酸水平。
