Pathology Department, Sancaktepe Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital, Istanbul 34785, Turkey.
Pathology Department, Istanbul University Cerrahpasa Medical Faculty, Istanbul 34096, Turkey.
Anal Cell Pathol (Amst). 2023 Jan 14;2023:2768344. doi: 10.1155/2023/2768344. eCollection 2023.
This study aimed to examine the incidence of incidental papillary microcarcinoma (PMC) and papillary thyroid carcinoma (PTC) in patients with benign multinodular goiter (MNG) and to compare their relationship with some prognostic factors from a new perspective.
Bilateral total thyroidectomy (BTT) was used to evaluate the data of 716 patients who underwent a surgery for MNG. The prognostic data for these tumors and the relationship between patients with bilateral and multifocal tumors were evaluated using statistical tests.
Papillary carcinomas were detected in 201 patients, PMC in 134 of them, and PTCs in 67. Bilaterality was more common in patients with PTCs than in those with PMC. The incidence of bilaterality in male patients with PTC was statistically more common. The presence of intra-tumoral lymphocytes was higher in multifocal PTC cases than in unifocal PTC cases.
The results revealed that the number of PMC s was high in incidental tumors, and patients with PTC with male sex, bilaterality, multifocality, and tumor capsule invasion were associated with poor prognosis.
本研究旨在探讨双侧甲状腺全切除术（BTT）治疗多发结节性甲状腺肿（MNG）患者时偶然发现的甲状腺微小乳头状癌（PMC）和甲状腺乳头状癌（PTC）的发生率，并从新的角度比较它们与一些预后因素的关系。
对 716 例行 MNG 手术的患者资料进行双侧甲状腺全切除术（BTT）评估。使用统计学检验评估这些肿瘤的预后数据以及双侧和多灶性肿瘤患者之间的关系。
201 例患者中发现了甲状腺癌，其中 134 例为 PMC，67 例为 PTC。与 PMC 相比，PTC 患者中双侧肿瘤更为常见。男性 PTC 患者双侧性的发生率具有统计学意义。多灶性 PTC 病例中的肿瘤内淋巴细胞比单灶性 PTC 病例更为常见。
结果表明，偶然肿瘤中 PMC 的数量较多，男性、双侧性、多灶性和肿瘤包膜侵犯的 PTC 患者与预后不良相关。
