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姜黄素通过上调 HO-1 表达诱导甲状腺滤泡癌细胞发生铁死亡。

Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.

机构信息

Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning Province, China.

出版信息

Oxid Med Cell Longev. 2023 Jan 14;2023:6896790. doi: 10.1155/2023/6896790. eCollection 2023.

DOI:10.1155/2023/6896790
PMID:36691638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9867595/
Abstract

Follicular thyroid cancer (FTC) is a highly aggressive type of endocrine malignancy. It is necessary to investigate the mechanisms of tumorigenesis and therapeutic pathways in patients with FTC. Haem oxygenase-1 (HO-1) can regulate oxidative stress and the occurrence of tumors and diseases. In this study, we discovered that HO-1 was abnormally overexpressed in FTC compared with adjacent tissues. However, the HO-1 overexpression was demonstrated to decrease cell viability and to potentially activate the ferroptosis signalling pathway. Ferroptosis is a newly identified form of oxidative cell death and is currently being targeted as a new cancer treatment. Tumorigenesis is significantly inhibited by curcumin. The present study shows that curcumin inhibits the growth of FTC by increasing the HO-1 expression, further activating the ferroptosis pathway. This study demonstrates that the HO-1-ferroptosis signalling pathway might play an important role in FTC tumorigenesis, and that curcumin inhibits the growth of FTC cells by affecting this pathway.

摘要

滤泡性甲状腺癌（FTC）是一种高度侵袭性的内分泌恶性肿瘤。有必要研究 FTC 患者的肿瘤发生机制和治疗途径。血红素加氧酶-1（HO-1）可以调节氧化应激和肿瘤及疾病的发生。在本研究中，我们发现与相邻组织相比，FTC 中 HO-1 异常过表达。然而，HO-1 的过表达被证明会降低细胞活力，并可能激活铁死亡信号通路。铁死亡是一种新发现的氧化细胞死亡形式，目前正被作为一种新的癌症治疗方法进行研究。姜黄素显著抑制肿瘤的发生。本研究表明，姜黄素通过增加 HO-1 的表达，进一步激活铁死亡途径，抑制 FTC 的生长。本研究表明，HO-1-铁死亡信号通路可能在 FTC 的肿瘤发生中起重要作用，而姜黄素通过影响该通路抑制 FTC 细胞的生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/62ed4f3f1061/OMCL2023-6896790.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/9ccefec7b433/OMCL2023-6896790.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/1e35a934731b/OMCL2023-6896790.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/2c755a2b3453/OMCL2023-6896790.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/3f478051a00e/OMCL2023-6896790.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/8f334d5673e7/OMCL2023-6896790.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/62ed4f3f1061/OMCL2023-6896790.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/9ccefec7b433/OMCL2023-6896790.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/1e35a934731b/OMCL2023-6896790.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/2c755a2b3453/OMCL2023-6896790.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/3f478051a00e/OMCL2023-6896790.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/8f334d5673e7/OMCL2023-6896790.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c21/9867595/62ed4f3f1061/OMCL2023-6896790.006.jpg

相似文献

[1]
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.

Oxid Med Cell Longev. 2023

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Cascade-penetrating domino-ferroptosis nano inducer synergizes with sonodynamic therapy for anaplastic thyroid cancer.

Mater Today Bio. 2025-8-16

[2]
Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

Front Oncol. 2025-6-9

[3]
Targeting ferroptosis: a novel insight into thyroid cancer therapy.

Front Endocrinol (Lausanne). 2025-6-3

[4]
Natural anti-cancer products: insights from herbal medicine.

Chin Med. 2025-6-9

[5]
Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis.

Mater Today Bio. 2025-3-5

[6]
Ferroptosis in thyroid cancer: mechanisms, current status, and treatment.

Front Oncol. 2025-1-23

[7]
Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS.

Sci Rep. 2024-12-4

[8]
Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis.

Int J Biol Sci. 2024

[9]
Curcumin Induces Autophagy-mediated Ferroptosis by Targeting the PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer.

Turk J Gastroenterol. 2024-7-3

[10]
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches.

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本文引用的文献

[1]
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.

Food Chem Toxicol. 2022-6

[2]
Stratification of follicular thyroid tumours using data-independent acquisition proteomics and a comprehensive thyroid tissue spectral library.

Mol Oncol. 2022-4

[3]
Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity.

Am J Cancer Res. 2021-6-15

[4]
The Diverse Roles of Heme Oxygenase-1 in Tumor Progression.

Front Immunol. 2021-3-31

[5]
Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression.

Int J Biochem Cell Biol. 2021-5

[6]
Tumor heterogeneity in autophagy-dependent ferroptosis.

Autophagy. 2021-11

[7]
Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells.

Oxid Med Cell Longev. 2020

[8]
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis.

Oxid Med Cell Longev. 2020-7-18

[9]
Versatile role of curcumin and its derivatives in lung cancer therapy.

J Cell Physiol. 2020-12

[10]
Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer.

Nutrients. 2020-3-2

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