Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Department of Ultrasonography, Xiangya Hospital, Central South University, Changsha, China.
Rheumatology (Oxford). 2023 Sep 1;62(9):3179-3187. doi: 10.1093/rheumatology/kead042.
Hand synovitis, a potentially modifiable pathological lesion, is common and associated with pain and hand OA; nevertheless, its pathogenesis remains uncertain. This study investigated the relationship between gut microbiota dysbiosis and hand synovitis prevalence and evaluated whether bile acids mediate the association.
Participants were derived from a community-based observational study. Synovitis in each hand joint was assessed using US. Gut microbiota was evaluated using 16S ribosomal RNA amplicon sequencing on faeces, and plasma bile acids were measured by HPLC mass spectrometry. We examined the relationship between gut microbiota dysbiosis and hand synovitis prevalence, as well as the extent to which bile acids were involved in the association.
Among 1336 participants (mean age: 63.2 years; women: 58.8%), 18.3% had prevalent hand synovitis (unilateral in 13.6% and bilateral in 4.7%). β-diversity, but not α-diversity, of gut microbiota was significantly associated with prevalent hand synovitis. Higher relative abundance of the genus Prevotella and lower relative abundance of the genus Blautia were significantly associated with the prevalence of hand synovitis. Similar associations were also observed for laterality and the number of joints affected by hand synovitis. The association between Prevotella and hand synovitis was partially mediated through its effect on tauroursodeoxycholic acid and glycoursodeoxycholic acid, the mediation proportions being 25.7% and 21.6%, respectively.
Our findings suggest that gut microbiota dysbiosis is associated with the prevalence of hand synovitis. Such an association appears to be partially mediated by plasma bile acids.
手部滑膜炎是一种潜在可改变的病理性病变，较为常见，与疼痛和手部骨关节炎有关；然而，其发病机制尚不清楚。本研究调查了肠道微生物群落失调与手部滑膜炎患病率之间的关系，并评估了胆汁酸是否介导了这种关联。
参与者来自一项基于社区的观察性研究。使用超声评估每只手关节的滑膜炎。通过粪便 16S 核糖体 RNA 扩增子测序评估肠道微生物群落，通过 HPLC 质谱法测量血浆胆汁酸。我们检查了肠道微生物群落失调与手部滑膜炎患病率之间的关系，以及胆汁酸在关联中的参与程度。
在 1336 名参与者中（平均年龄：63.2 岁；女性：58.8%），18.3%患有手部滑膜炎（单侧 13.6%，双侧 4.7%）。肠道微生物群落的 β 多样性，但不是 α 多样性，与手部滑膜炎的患病率显著相关。普雷沃氏菌属的相对丰度较高，而布劳特氏菌属的相对丰度较低，与手部滑膜炎的患病率显著相关。对于手滑膜炎的侧别和受累关节数也观察到类似的关联。普雷沃氏菌属与手部滑膜炎之间的关联部分通过其对牛磺熊去氧胆酸和甘氨熊去氧胆酸的影响来介导，介导比例分别为 25.7%和 21.6%。
我们的研究结果表明，肠道微生物群落失调与手部滑膜炎的患病率有关。这种关联似乎部分是通过血浆胆汁酸介导的。
