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[这些寄居于我们并侵袭我们的病毒:人类病毒组]

[These viruses that inhabit and visit us: The human virome].

作者信息

Ottmann Michèle

机构信息

Centre international de recherche en infectiologie (CIRI), université Claude Bernard-Lyon 1, université de Lyon, Inserm U1111 - CNRS UMR 5308 - ENS, Laboratoire de virologie et pathologies humaines, Faculté de médecine RTH Laennec, 7 rue Guillaume Paradin, 69372 Lyon cedex 08, France.

出版信息

Med Sci (Paris). 2022 Dec;38(12):1028-1038. doi: 10.1051/medsci/2022161. Epub 2022 Dec 13.

Abstract

Recent advances in new sequencing technologies have opened the way to the deciphering of human virome. So far, human virome is defined as the complete list of viruses found in human body. Those viruses could be endogenous, prokaryotic, archaeal and eukaryotic. In addition, each compartment of the human body constitutes a different microenvironment with its own virome. Viral infections can be categorized according to the outcome of the acute phase and until recently, only symptomatic and pathological infections were studied. It is now well established that a healthy person has an extremely diverse virome. This review summarizes the current state of our knowledge and also proposes another classification of the human virome based on principles of ecology.

摘要

新测序技术的最新进展为人类病毒组的解密开辟了道路。到目前为止,人类病毒组被定义为在人体中发现的病毒的完整清单。这些病毒可以是内源性、原核、古细菌和真核的。此外,人体的每个腔室都构成了一个具有自身病毒组的不同微环境。病毒感染可以根据急性期的结果进行分类,直到最近,仅研究了有症状和病理性感染。现在已经明确,健康人具有极其多样的病毒组。这篇综述总结了我们目前的知识状态,并基于生态学原理提出了人类病毒组的另一种分类。

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