Musazadeh Vali, Karimi Arash, Malekahmadi Mahsa, Ahrabi Sana Sedgh, Dehghan Parvin
Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Exp Pharmacol Physiol. 2023 May;50(5):327-334. doi: 10.1111/1440-1681.13750. Epub 2023 Feb 14.
There has been conflicting evidence from meta-analyses on the effect of polyunsaturated fatty acids (PUFA) on non-alcoholic fatty liver disease (NAFLD). Therefore, in this umbrella meta-analysis, we are evaluating whether omega-3 PUFA supplementation has any benefit in treating NAFLD. Electronic databases such as PubMed, Web of Science, Scopus, Embase and Google Scholar were assessed to October 2022. This meta-analysis included all meta-analyses that examined the effect of PUFAs on liver fat and liver function tests [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT)]. Meta-analysis was conducted using a random effects model. Subgroup analyses and sensitivity analyses were also performed. In total, eight articles involving 6,561 participants met the eligibility criteria. Advantageous impacts PUFA supplementation were observed on ALT (ES = -6.72 IU/L; 95% CI: -8.61, -4.84; p < 0.001, and ES = -0.52 IU/L; 95% CI: -0.84, -0.20, p < 0.001), AST (ES = -3.73 IU/L, 95% CI: -5.93, -1.53, p < 0.001, and ES = -0.65 IU/L; 95% CI: -1.08, -0.22, p = 0.003), GGT levels (ES = -4.20 IU/L, 95% CI: -6.85, -1.55, p = 0.002), and liver fat (ES = -5.16; 95% CI: -8.49, -1.82, p < 0.001). Intervention with omega-3 PUFAs improves ALT, AST, GGT, and liver fat in patients with NAFLD. Thus, omega-3 PUFAs could be considered as a therapeutic option in the treatment of NAFLD.
关于多不饱和脂肪酸（PUFA）对非酒精性脂肪性肝病（NAFLD）影响的荟萃分析结果存在相互矛盾的证据。因此，在这项伞状荟萃分析中，我们正在评估补充ω-3多不饱和脂肪酸对治疗NAFLD是否有任何益处。对PubMed、科学网、Scopus、Embase和谷歌学术等电子数据库进行了评估，截至2022年10月。这项荟萃分析纳入了所有研究多不饱和脂肪酸对肝脏脂肪和肝功能检查[天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转移酶（GGT）]影响的荟萃分析。使用随机效应模型进行荟萃分析。还进行了亚组分析和敏感性分析。总共八篇涉及6561名参与者的文章符合纳入标准。观察到补充多不饱和脂肪酸对ALT（效应量= -6.72 IU/L；95%置信区间：-8.61，-4.84；p < 0.001，效应量= -0.52 IU/L；95%置信区间：-0.84，-0.20，p < 0.001）、AST（效应量= -3.73 IU/L，95%置信区间：-5.93，-1.53，p < 0.001，效应量= -0.65 IU/L；95%置信区间：-1.08，-0.22，p = 0.003）、GGT水平（效应量= -4.20 IU/L，95%置信区间：-6.85，-1.55，p = 0.002）和肝脏脂肪（效应量= -5.16；95%置信区间：-8.49，-1.82，p < 0.001）有有利影响。用ω-3多不饱和脂肪酸进行干预可改善NAFLD患者的ALT、AST、GGT和肝脏脂肪。因此，ω-多不饱和脂肪酸可被视为治疗NAFLD的一种治疗选择。
