Ikeda T, Sakai T, Nishimura Y
Department of Surgery, Tokyo Metropolitan Komagome Hospital.
Jpn J Antibiot. 1987 May;40(5):946-50.
Concentrations of cefpiramide (CPM) in human lung tissues were determined after 1 g intravenous bolus injection in 6 patients with lung tumors and pyothorax. Concentrations of the CPM in blood and lung tissues were determined and analyzed pharmacokinetically. Levels of CPM in the lung tissues reached 38.4 micrograms/g at 2 hours and declined to 27.7 micrograms/g in 6 hours. Levels of CPM in the lung tissues were higher than 50% of those in the serum between 100 minutes and 360 minutes after the administration of CPM.
对6例患有肺部肿瘤和脓胸的患者静脉推注1克头孢匹胺（CPM）后，测定了人肺组织中CPM的浓度。测定了血液和肺组织中CPM的浓度，并进行了药代动力学分析。肺组织中CPM的浓度在2小时时达到38.4微克/克，并在6小时内降至27.7微克/克。在给予CPM后100分钟至360分钟之间，肺组织中CPM的浓度高于血清中CPM浓度的50%。
