纳米颗粒通过瞬时蛋白质冠层与受损血管中的内皮细胞结合。
Nanoparticles Bind to Endothelial Cells in Injured Blood Vessels via a Transient Protein Corona.
作者信息
Lin Zachary P, Ngo Wayne, Mladjenovic Stefan M, Wu Jamie L Y, Chan Warren C W
机构信息
Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Terrence Donnelly Center for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5 3E1, Canada.
出版信息
Nano Lett. 2023 Feb 8;23(3):1003-1009. doi: 10.1021/acs.nanolett.2c04501. Epub 2023 Jan 24.
Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may interact with a highly localized concentration of platelet factor 4 proteins released from activated platelets. The platelet factor 4 binds to the nanoparticle surface and interacts with heparan sulfate proteoglycans on endothelial cells, and induces uptake. Understanding nanoparticle interactions with blood proteins and endothelial cells during circulation is critical to optimizing their design for diseased tissue targeting and delivery.
纳米颗粒通过血管到达疾病部位，但它们遇到的局部环境可能会影响其表面化学性质和细胞相互作用。在这里，我们发现，当纳米颗粒穿过受损血管时，它们可能会与从活化血小板释放的高度局部化的血小板因子4蛋白浓度相互作用。血小板因子4与纳米颗粒表面结合，并与内皮细胞上的硫酸乙酰肝素蛋白聚糖相互作用，从而诱导摄取。了解纳米颗粒在循环过程中与血液蛋白和内皮细胞的相互作用对于优化其针对患病组织的靶向和递送设计至关重要。
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