Qin Guanghao, Chen Jiayan, Li Liangzhe, Xia Yang, Zhang Qing, Wu Yi, Yang Lanting, Moutari Salissou, Moore Jonathan E, Xu Ling, He Wei, Yu Sile, He Xingru, Pazo Emmanuel Eric
Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, 110034, China.
Tianjin Medical Eye Hospital, Tianjin, China.
Ophthalmol Ther. 2023 Apr;12(2):1059-1071. doi: 10.1007/s40123-023-00649-5. Epub 2023 Jan 24.
This study assessed the efficacy and safety of intense pulsed light (IPL) therapy in participants with severe evaporative dry eye disease (DED).
This randomized, controlled, single-center study included 49 adult participants (≥ 18 years) with severe evaporative DED who received either IPL therapy (n = 56 eyes) or sham therapy (n = 42 eyes) three times. The primary efficacy parameters were ocular surface disease index (OSDI) score, non-invasive tear breakup time (NITBUT), tear film lipid layer (TFLL), conjunctivocorneal staining score (CS), MG Score, meibomian gland (MG) quality, and MG expression score.
The mean ages for the IPL group and the control group were 28.05 ± 3.41 years (57.1% female) and 28.14 ± 3.53 years (52.4% female), respectively. Comparison between the IPL group and the control group found significant differences in the mean OSDI score (22.16 ± 6.08 vs. 42.38 ± 6.60; P < 00.01), NITBUT (6.27 ± 0.84 vs. 3.86 ± 0.68; P < 0.001), TFLL (2.14 ± 0.44 vs. 3.45 ± 0.50; P < 0.001), MG Score (1.34 ± 0.55 vs. 1.88 ± 0.33; P < 0.001), MG quality (1.59 ± 0.07 vs. 2.67 ± 0.08), and MG expression (1.54 ± 0.57 vs. 2.45 ± 0.55) at 12 weeks follow-up; however, there was no significant difference in CS (3.32 ± 1.11 vs. 3.74 ± 1.04; P = 0.063).
The findings suggest that IPL therapy is clinically beneficial in ameliorating the signs and symptoms of severe evaporative dry eye disease.
本研究评估了强脉冲光（IPL）疗法对严重蒸发型干眼症（DED）患者的疗效和安全性。
这项随机、对照、单中心研究纳入了49名年龄≥18岁的严重蒸发型DED成年患者，他们接受了3次IPL治疗（n = 56只眼）或假治疗（n = 42只眼）。主要疗效参数包括眼表疾病指数（OSDI）评分、无创泪膜破裂时间（NITBUT）、泪膜脂质层（TFLL）、结膜角膜染色评分（CS）、睑板腺评分（MG Score）、睑板腺（MG）质量和MG表达评分。
IPL组和对照组的平均年龄分别为28.05±3.41岁（女性占57.1%）和28.14±3.53岁（女性占52.4%）。IPL组与对照组比较，在随访12周时，平均OSDI评分（22.16±6.08 vs. 42.38±6.60；P<0.001）、NITBUT（6.27±0.84 vs. 3.86±0.68；P<0.001）、TFLL（2.14±0.44 vs. 3.45±0.50；P<0.001）、MG评分（1.34±0.55 vs. 1.88±0.33；P<0.001）、MG质量（1.59±0.07 vs. 2.67±0.08）和MG表达（1.54±0.57 vs. 2.45±0.55）存在显著差异；然而，CS方面无显著差异（3.32±1.11 vs. 3.74±1.04；P = 0.063）。
研究结果表明，IPL疗法在改善严重蒸发型干眼症的体征和症状方面具有临床益处。
