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利用毛细管电泳迁移位置对中国常见血红蛋白变异体进行初步鉴定

Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China.

作者信息

Xu Miao, Li Ming-Yang, Zeng Yu, Xie Weijie, Xu An-Ping, Ji Ling

机构信息

Department of Laboratory Medicine, Weifang People's Hospital, Weifang, Shandong Province, People's Republic of China.

Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People's Republic of China.

出版信息

Hemoglobin. 2022 Nov;46(6):330-334. doi: 10.1080/03630269.2022.2151463. Epub 2023 Jan 25.

Abstract

Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.

摘要

毛细管电泳(CE)越来越多地用于血红蛋白病的筛查。我们在此报告通过CE测定的中国常见血红蛋白(Hb)变异体的迁移位置。CE迁移位置显示出极佳的精密度和较小的个体间差异。我们得出结论,CE迁移位置可作为鉴定Hb变异体的可靠指标,也有助于建立一个特征明确的Hb变异体库,用于其精确的初步鉴定。

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