Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Internal Diseases, Metabolism and Nutrition, Poznan University of Medical Science, Poznan, Poland.
J Physiol Pharmacol. 2022 Aug;73(4). doi: 10.26402/jpp.2022.4.06. Epub 2023 Jan 20.
Deficiency of a soluble form of the advanced glycation end products receptor (sRAGE) is implicated in obesity-induced complications. Serum sRAGE is inclined to be modified by changes in body weight. We analysed serum sRAGE concentrations in patients with obesity undergoing moderate calorie restriction, which mimics the real-life situation and is not harmful to obese humans. Serum sRAGE was measured by immunoassay in 50 patients with obesity who underwent calorie restriction by 300-500 kcal/day for 8 weeks. In effect calorie restriction resulted in an expected decrease in body weight (by 2.1 kg for an 8-week intervention, p<0.0001), as well as reduced systolic blood pressure, modified dyslipidemia (cholesterol, triglycerides), reduced obesity-related inflammation (tumor necrosis factor-alfa, interleukin-6, C-reactive protein), improved insulin sensitivity. However, it was not accompanied by any significant change in sRAGE concentration. There was a strong negative correlation between BMI and the sRAGE level. Accordingly, the levels of sRAGE were the highest in lean control. In conclusion: a modest weight reduction is unlikely to improve decreased sRAGE levels.
可溶性晚期糖基化终产物受体（sRAGE）缺乏与肥胖引起的并发症有关。血清 sRAGE 容易受到体重变化的影响。我们分析了接受适度热量限制的肥胖患者的血清 sRAGE 浓度，这种限制模拟了现实生活中的情况，对肥胖人群没有危害。对 50 名接受 300-500 卡路里/天热量限制 8 周的肥胖患者进行了免疫测定，以测量血清 sRAGE。事实上，热量限制导致体重预期下降（8 周干预期间下降 2.1 公斤，p<0.0001），收缩压降低，血脂异常得到改善（胆固醇、甘油三酯），肥胖相关炎症减轻（肿瘤坏死因子-α、白细胞介素-6、C 反应蛋白），胰岛素敏感性提高。然而，sRAGE 浓度并没有随之发生任何显著变化。BMI 与 sRAGE 水平之间存在强烈的负相关。因此，瘦对照组的 sRAGE 水平最高。总之：适度减轻体重不太可能改善降低的 sRAGE 水平。
