Grupo de Investigación de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Grupo de Investigación de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Med Clin (Barc). 2023 May 26;160(10):428-433. doi: 10.1016/j.medcli.2022.11.019. Epub 2023 Jan 23.
The aim of this research was to investigate the relationship between disease activity and health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE) considering the increased interest in the management of this disease.
HRQoL was measured at clinic visits during a 12-month follow-up period using questionnaires on fatigue (FACIT-FATIGUE); quality of life, EuroQol 5-dimension (EQ-5D-5L) health questionnaire with 5 levels; disability, Health Assessment Questionnaire (HAQ), and a Global Health Status (GHS) scale. Disease activity, organ damage and other clinical factors that could affect HRQoL were recorded. The association between disease activity and HRQoL was assessed using Bayesian linear regression models with monotonic effects.
Data from 70 patients at the baseline visit and 42 patients with 1 year of follow-up were analyzed. At baseline, 28.57% of patients presented Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)>6. In the 70 baseline patients, disease activity was associated with HRQoL in all four parameters. In the 42 patients with 12 months of follow-up, the positive association of disease activity with GHS, FACIT-FATIGUE and EQ-5D-5L and the negative association with HAQ was maintained. Patients who are smokers and those receiving immunosuppressant therapy presented low GHS and FACIT-FATIGUE scores. Moreover, older age at inclusion was significantly associated to low GHS, while low leucocyte and 25-OH-vitamin D levels were associated to fatigue perception in SLE patients.
Our results showed a statistically significant association between disease activity and HRQoL parameters.
本研究旨在探讨系统性红斑狼疮（SLE）患者疾病活动与健康相关生活质量（HRQoL）之间的关系，因为人们对这种疾病的管理越来越感兴趣。
在 12 个月的随访期间，通过疲劳量表（FACIT-FATIGUE）、欧洲五维健康量表（EQ-5D-5L）5 级健康问卷、残疾量表（HAQ）和全球健康状况量表（GHS）在就诊时评估 HRQoL。记录疾病活动、器官损伤和其他可能影响 HRQoL 的临床因素。使用具有单调效应的贝叶斯线性回归模型评估疾病活动与 HRQoL 之间的关联。
对基线就诊时的 70 名患者和 1 年随访的 42 名患者进行了数据分析。基线时，28.57%的患者出现系统性红斑狼疮疾病活动指数（SLEDAI）>6。在 70 名基线患者中，疾病活动与所有四个参数的 HRQoL 相关。在 42 名随访 12 个月的患者中，疾病活动与 GHS、FACIT-FATIGUE 和 EQ-5D-5L 呈正相关，与 HAQ 呈负相关。吸烟者和接受免疫抑制剂治疗的患者 GHS 和 FACIT-FATIGUE 评分较低。此外，纳入时年龄较大与 GHS 评分较低显著相关，而白细胞和 25-OH-维生素 D 水平较低与 SLE 患者的疲劳感相关。
我们的研究结果显示疾病活动与 HRQoL 参数之间存在统计学显著关联。
