系统性红斑狼疮患者的认知障碍：患病率及其与生活质量的关联。

Cognitive impairment in systemic lupus erythematosus patients: prevalence and its association with quality of life.

作者信息

Ginayah Mir'atul, Widhani Alvina, Estiasari Riwanti, Koesnoe Sukamto, Maria Suzy, Anggoro Kusumo Wibowo Raden Mas Suryo, Soewondo Pradana, Shatri Hamzah, Prawiroharjo Pukovisa, Sari Nina Kemala, Rizka Aulia

机构信息

Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Allergy & Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

出版信息

BMC Rheumatol. 2025 Mar 28;9(1):37. doi: 10.1186/s41927-025-00486-y.

DOI:10.1186/s41927-025-00486-y

PMID:40148993

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11951722/

Abstract

BACKGROUND

Cognitive impairment among patients with systemic lupus erythematosus (SLE) can significantly impact quality of life (QoL). This study aimed to determine the prevalence of cognitive impairment in SLE patients using the Montreal Cognitive Assessment Indonesian version (MoCA-INA) and to assess its association with QoL.

METHODS

This was a cross-sectional study of SLE patients from the outpatient clinic at Cipto Mangunkusumo Hospital, Jakarta. Data collected included patient characteristics, MoCA-INA scores, the LupusQoL questionnaire, and the Hospital Anxiety and Depression Scale (HADS) scores. The independent T-test or Mann-Whitney U test was used to analyze the association between categorical independent variables and LupusQoL, while Spearman or Pearson correlation tests were used to examine the association between numerical independent variables and QoL. Other factors potentially associated with QoL - including disease duration, age, education level, comorbidities, disease activity, organ involvement, steroid dose, immunosuppressant medication, anxiety, and depression - were also assessed. A p-value < 0.05 was considered statistically significant.

RESULTS

Of the 116 subjects, 112 (96.6%) were female, with a mean age of 34.41 (± 10.15) years. Most participants had completed secondary education, were receiving corticosteroids, and had been prescribed hydroxychloroquine. The median MEX-SLEDAI score was 2.75 (range 0-6), and the most common organ involvements were mucocutaneous (90.5%) and musculoskeletal (91.4%) manifestations. The prevalence of cognitive impairment in SLE patients was 57.8%, with most patients experiencing mild cognitive impairment (98.5%). There was no significant difference in QoL between SLE patients with and without cognitive impairment (p = 0.750). Disease duration (r = 0.24, p = 0.011), anxiety (p < 0.001), and depression (p = 0.003) were significantly associated with QoL among SLE patients.

CONCLUSIONS

More than half of the subjects experienced cognitive impairment. However, there was no significant difference in QoL between SLE patients with and without cognitive impairment.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

系统性红斑狼疮（SLE）患者的认知障碍会显著影响生活质量（QoL）。本研究旨在使用印度尼西亚语版蒙特利尔认知评估量表（MoCA-INA）确定SLE患者认知障碍的患病率，并评估其与生活质量的关联。

方法

这是一项对雅加达Cipto Mangunkusumo医院门诊SLE患者的横断面研究。收集的数据包括患者特征、MoCA-INA评分、狼疮生活质量问卷以及医院焦虑抑郁量表（HADS）评分。采用独立样本t检验或曼-惠特尼U检验分析分类自变量与狼疮生活质量之间的关联，同时采用斯皮尔曼或皮尔逊相关检验来检验数值自变量与生活质量之间的关联。还评估了其他可能与生活质量相关的因素，包括疾病持续时间、年龄、教育水平、合并症、疾病活动度、器官受累情况、类固醇剂量、免疫抑制药物、焦虑和抑郁。p值<0.05被认为具有统计学意义。

结果

116名受试者中，112名（96.6%）为女性，平均年龄为34.41（±10.15）岁。大多数参与者完成了中等教育，正在接受皮质类固醇治疗，并已被处方使用羟氯喹。MEX-SLEDAI评分中位数为2.75（范围0-6），最常见的器官受累表现为皮肤黏膜（90.5%）和肌肉骨骼（91.4%）表现。SLE患者认知障碍的患病率为57.8%，大多数患者为轻度认知障碍（98.5%）。有认知障碍和无认知障碍的SLE患者在生活质量方面无显著差异（p=0.750）。疾病持续时间（r=0.24，p=0.011）、焦虑（p<0.001）和抑郁（p=0.003）与SLE患者的生活质量显著相关。