College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, 1239 Siping Road, Shanghai, 200092, PR China.
School of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong, Shenzhen City, Guangdong, 518172, PR China.
Nat Commun. 2023 Jan 25;14(1):409. doi: 10.1038/s41467-023-36115-w.
Nonconjugated and nonaromatic luminophores based on clustering-triggered emission derived from through-space conjugation have drawn emerging attention in recent years. The reported nonconventional luminophores are emissive in concentrated solution and/or in the solid state, but they tend to be nonluminescent in dilute solution, which greatly limits their sensing and imaging applications. Herein, we design unique clusteroluminogens through modification of cyclodextrin (CD) with amino acids to enable the intermolecular and intramolecular clusterization of chromophores in CD-based confined space. The resulted through-space interactions along with conformation rigidification originated from hydrogen bond interaction and complexation interaction generate blue to cyan fluorescence even in the dilute solution (0.035 wt.%, quantum yield of 40.70%). Moreover, the prepared histidine-modified CD (CDHis) is demonstrated for fluorescent detection of chlortetracycline with high sensitivity and selectivity. This work provides a new and universal strategy to synthesize nonconventional luminophores with bright fluorescence in dilute aqueous solution through molecular-level enhanced clusterization-triggered emission.
近年来，基于通过空间共轭引发的聚集诱导发射的非共轭和非芳香发光团引起了人们的关注。报道的非常规发光团在浓溶液和/或固态中是发光的，但在稀溶液中往往是非发光的，这极大地限制了它们的传感和成像应用。在此，我们通过用氨基酸修饰环糊精（CD）来设计独特的团簇发光团，以实现基于 CD 的受限空间中发色团的分子间和分子内聚集。所得的通过空间相互作用以及源于氢键相互作用和络合相互作用的构象固定化产生了蓝色到青色的荧光，即使在稀溶液中（0.035wt%，量子产率为 40.70%）也是如此。此外，所制备的组氨酸修饰的 CD（CDHis）被证明可用于高灵敏度和选择性地检测金霉素。这项工作提供了一种新的通用策略，通过分子水平增强的聚集诱导发射，在稀水溶液中合成具有明亮荧光的非传统发光团。
