Division of Neonatal and Perinatal Medicine, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA.
J Perinatol. 2023 Apr;43(4):470-476. doi: 10.1038/s41372-023-01610-x. Epub 2023 Jan 25.
To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD).
In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6).
Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29-0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03).
Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood.
Trial Registration numbers: Clinicaltrials.gov NCT03423836.
评估在怀孕期间（干预组）而非产后（对照组）治疗母体牙周病（一种促炎状态）是否降低了后代自闭症谱系障碍（ASD）筛查阳性的可能性。
在 MOTOR 随机试验的随访研究中，我们比较了 n=306 名两岁大的幼儿在Modified Checklist for Autism in Toddlers（M-CHAT）上的阳性筛查率，并将结果与母体和脐带血促炎白细胞介素-6（IL-6）相关联。
干预组的幼儿 M-CHAT 筛查阳性的风险降低（调整 RR=0.53，95%CI 0.29-0.99）。与阴性筛查相比，阳性筛查的幼儿脐带血中 IL-6 平均值更高（1.58±1.14 比 1.09±0.72，p=0.001），且母体 IL-6 从基线的变化更大（1.30±0.61 比 0.96±0.62，p=0.03）。
在怀孕期间治疗牙周病降低了 ASD 筛查阳性的风险。M-CHAT 阳性与母体和脐带血中 IL-6 增加有关。
临床试验注册号：Clinicaltrials.gov NCT03423836。
