Kanlayavattanakul Mayuree, Lourith Nattaya
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, Thailand.
Fungal Biol Biotechnol. 2023 Jan 25;10(1):3. doi: 10.1186/s40694-023-00150-5.
Topical product derived from the fungus Cordyceps militaris was explored as a feasible method for an industrial practice.
The mycelium residue of C. militaris that was industrial biotechnological produced was extracted with water at different time conditions under ambient temperature, filtered and lyophilized. The extracts were all light to dark brown powder. The 24 h extraction was significantly (p < 0.01) highest in an extractive yield and total polysaccharides content (TPC) (43.33 ± 0.99% and 144.02 ± 2.06 mg glucose/g crude extract). This extract was proved to be stable following an accelerated stability test with the insignificant (p > 0.05) reduction of TPC (4.95 ± 2.23%). Topical product containing the extract were developed. Skin care preparation containing 0.2% extract was exhibited as the appropriated amount giving the stable cream. The developed C. militaris polysaccharide cream was confirmed safe and gained more than 70% of the overall preferences examined in 20 female volunteers.
Cordyceps militaris mycelium residue is a beneficial source for pharmaceutical products. The C. militaris polysaccharides extract was prepared and qualified in terms of active content and stability. The extract was shown to be compatible with the available cosmetic ingredients. The safe and preferred C. militaris polysaccharides skin care cosmetics was developed. Accordingly, C. militaris polysaccharides skin care cosmetics that meets all the quality characters which are stable, safe, usable and efficient.
探索了从蛹虫草中提取的外用产品作为一种可行的工业生产方法。
将通过工业生物技术生产的蛹虫草菌丝体残渣在环境温度下于不同时间条件下用水提取，过滤并冻干。提取物均为浅棕色至深棕色粉末。24小时提取的提取物得率和总多糖含量（TPC）显著最高（p <0.01）（43.33±0.99%和144.02±2.06毫克葡萄糖/克粗提取物）。经过加速稳定性试验，该提取物被证明是稳定的，TPC降低不显著（p>0.05）（4.95±2.23%）。开发了含有该提取物的外用产品。含有0.2%提取物的护肤品表现为制成稳定乳膏的适宜用量。所开发的蛹虫草多糖乳膏经证实是安全的，在20名女性志愿者中获得了超过70%的总体偏好。
蛹虫草菌丝体残渣是药品的有益来源。制备了蛹虫草多糖提取物，并在活性成分和稳定性方面进行了鉴定。该提取物与现有的化妆品成分相容。开发了安全且受欢迎的蛹虫草多糖护肤品。因此，蛹虫草多糖护肤品符合所有稳定、安全、可用和高效的质量特性。
