Haroon Maysa M, Hegazy Gehan A, Hassanien Mohammed A, Shaker Olfat, Hussein Wafaa H
Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Biologics. 2023 Jan 18;17:1-9. doi: 10.2147/BTT.S389021. eCollection 2023.
Dysregulation of both cellular and humoral immune responses is central in systemic lupus erythematosus (SLE) pathogenetic mechanisms. Proinflammatory cytokines, such as interleukin 23 (IL23), and their roles in promoting such dysregulation have recently been highly considered. This research compared IL23 serum levels in 85 Egyptian SLE patients and 85 healthy controls. Then, IL23 level was correlated to various SLE disease parameters, disease activity, and damage indices.
IL23 serum levels were significantly elevated in SLE patients versus healthy individuals. Furthermore, IL23 levels were positively correlated with SLE disease activity index (SLEDAI) and were positively correlated with arthritis, seizures, consumption of complements (C3, C4), and with parameters of nephritis (hematuria, pyuria, casts, and proteinuria). A positive correlation was also found between IL23 levels and oral prednisolone dose.
IL23 has higher levels in the serum of SLE patients, and is correlated to activity of the disease, especially lupus nephritis. Further researchis needed to explore its exact role in SLE pathogenesis and whether it can be considered a potential biomarker or therapeutic target in SLE.
细胞免疫和体液免疫反应的失调是系统性红斑狼疮（SLE）发病机制的核心。促炎细胞因子，如白细胞介素23（IL23），及其在促进这种失调中的作用最近受到高度关注。本研究比较了85例埃及SLE患者和85例健康对照者的IL23血清水平。然后，将IL23水平与各种SLE疾病参数、疾病活动度和损伤指数进行关联。
与健康个体相比，SLE患者的IL23血清水平显著升高。此外，IL23水平与SLE疾病活动指数（SLEDAI）呈正相关，与关节炎、癫痫发作、补体消耗（C3、C4）以及肾炎参数（血尿、脓尿、管型和蛋白尿）呈正相关。IL23水平与口服泼尼松龙剂量之间也存在正相关。
SLE患者血清中IL23水平较高，且与疾病活动度相关，尤其是狼疮性肾炎。需要进一步研究以探索其在SLE发病机制中的确切作用，以及它是否可被视为SLE的潜在生物标志物或治疗靶点。
