用于可控药物递送系统的刺激响应性可注射壳聚糖基水凝胶

Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems.

作者信息

Garshasbi Hamidreza, Salehi Saba, Naghib Seyed Morteza, Ghorbanzadeh Sadegh, Zhang Wei

机构信息

Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology and Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, Iran University of Science and Technology (IUST), The Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.

State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.

出版信息

Front Bioeng Biotechnol. 2023 Jan 6;10:1126774. doi: 10.3389/fbioe.2022.1126774. eCollection 2022.

DOI:10.3389/fbioe.2022.1126774

PMID:36698640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9869377/

Abstract

In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.

摘要

在过去十年中，可注射水凝胶因其在药物递送领域的优异功能特性，能够实现精确、无创且靶向特定组织部位，而备受关注。因此，设计对水凝胶刺激有响应的药物递送系统（DDS），使其能对外界刺激释放药物并具备多种优势，极具挑战性。基于壳聚糖（Chitosan）的水凝胶因其生物相容性、黏膜黏附性和止血活性，在组织工程和药物递送方面具有很大潜力。这些刺激响应性壳聚糖水凝胶的结构可能难以控制，或者可能需要额外的交联剂，比如具有双重pH和热响应性的水凝胶。因此，制备这些用于医学应用的水凝胶至关重要。