大鼠腿部肌肉中31P自旋弛豫时间（T1、T2、T1ρ）的体内测定。离轴螺线管线圈的应用。

In vivo determination of 31P spin relaxation times (T1, T2, T1 rho) in rat leg muscle. Use of an off-axis solenoid coil.

作者信息

Brooks W M, Field J, Irving M G, Doddrell D M

机构信息

School of Science, Griffith University, Nathan, Australia.

出版信息

Magn Reson Imaging. 1986;4(3):245-50. doi: 10.1016/0730-725x(86)91065-9.

DOI:10.1016/0730-725x(86)91065-9

PMID:3669937

Abstract

A probe using a solenoid coil tilted 45 degrees off-axis has been used to study the 31P NMR relaxation characteristics of the resonances arising from phosphorus metabolites in rats in vivo. T1, T1 rho and T2 values have been determined for phosphocreatine and ATP in leg muscle. The ratio of 31P T1(1700ms) to T2(12ms) for ATP was in excess of 200:1 compared with a ratio of 5:1 for 1H T1:T2. Of major significance was the observation that T2 values for phosphocreatine (230ms) were markedly longer than T2 values for ATP (12ms). Thus by use of appropriate delay times in spin echo sequences ATP signals can be nulled, and discrete 31P imaging of phosphocreatine in muscle may be possible provided the overall signal-to-noise is satisfactory.

摘要

一种使用偏离轴45度倾斜的螺线管线圈的探头已被用于研究大鼠体内磷代谢物产生的共振的31P NMR弛豫特性。已经测定了腿部肌肉中磷酸肌酸和ATP的T1、T1ρ和T2值。ATP的31P T1（1700毫秒）与T2（12毫秒）之比超过200:1，而1H T1:T2之比为5:1。具有重要意义的是观察到磷酸肌酸的T2值（230毫秒）明显长于ATP的T2值（12毫秒）。因此，通过在自旋回波序列中使用适当的延迟时间，可以使ATP信号归零，并且只要整体信噪比令人满意，就有可能对肌肉中的磷酸肌酸进行离散的31P成像。