Department of Digestive Diseases, Shandong Public Health Clinical Center, Shandong University, Jinan, China.
Department of Medical Service, Shandong Public Health Clinical Center, Shandong University, Jinan, China.
Front Public Health. 2023 Jan 9;10:1046112. doi: 10.3389/fpubh.2022.1046112. eCollection 2022.
To investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19.
This quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. Patients were divided into two groups to receive Lianhua Qingwen granules and traditional Chinese medicine (TCM) prescriptions (conventional group) and 3% hypertonic saline nasal irrigation based on conventional treatment (nasal irrigation groups), respectively. Primary outcomes were symptom disappearance time and nucleic acid negative conversion time. Secondary outcomes were peripheral blood white blood cell (WBC), lymphocyte (LYM) count, neutrophil (NEU) count, C-reactive protein (CRP) level, and chest CT examination findings.
Eighty patients were included (40 patients/group). Multiple linear regression analysis showed that, after adjustment for comorbidities, smoking history, LYM count, and Ct values of N gene, the patients in the nasal irrigation group were more likely to get lower nucleic acid negative conversion time (β = -11.052, 95% CI: -8.277-13.827, < 0.001) compared with the conventional group. The symptom disappearance time showed no significant improvement ( > 0.05). Subgroup analysis for treatment-naïve patients in the nasal irrigation group showed similar nucleic acid negative conversion time improvement ( = 0.038).
Early nasal irrigation shortens the nucleic acid negative conversion time in adults infected with the Omicron variant but without improvements in symptom disappearance time.
研究鼻腔冲洗对感染奥密克戎变异株的成年人症状持续时间和核酸转换的影响。
本准实验研究纳入 2022 年 4 月 1 日至 5 月 1 日在山东省公共卫生临床中心诊断为无症状、轻症或中症奥密克戎感染的患者。患者分为两组，分别接受连花清瘟颗粒和中药（TCM）方剂（常规组）以及基于常规治疗的 3%高渗盐水鼻腔冲洗（鼻腔冲洗组）。主要结局是症状消失时间和核酸阴性转换时间。次要结局是外周血白细胞（WBC）、淋巴细胞（LYM）计数、中性粒细胞（NEU）计数、C 反应蛋白（CRP）水平和胸部 CT 检查结果。
共纳入 80 例患者（每组 40 例）。多线性回归分析表明，在校正合并症、吸烟史、LYM 计数和 N 基因 Ct 值后，鼻腔冲洗组患者的核酸阴性转换时间更短（β=-11.052，95%CI：-8.277-13.827， < 0.001）。症状消失时间无显著改善（ > 0.05）。鼻腔冲洗组治疗初治患者的亚组分析显示，核酸阴性转换时间也有所改善（ = 0.038）。
早期鼻腔冲洗可缩短感染奥密克戎变异株成年人的核酸阴性转换时间，但对症状消失时间无改善。
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