Liao Li-Lan, Wang Chien-Chun, Wu Chien-Lung, Chu Yi-Shun, Chou Yi-Chang, Hsu Chung-Hua
Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department of Chinese Medicine, Taipei City Hospital, Linsen Chinese Medicine and Kunming Branch, Taipei, Taiwan.
Evid Based Complement Alternat Med. 2023 Jan 16;2023:9445111. doi: 10.1155/2023/9445111. eCollection 2023.
This study explored the pathological constitution as it relates to low quality of life in HIV-infected MSM patients, as a reference for clinical treatment.
It had a cross-sectional research design using structured questionnaires to collect data, including patient's basic data, CD4, CD4/CD8 ratio, Wang Qi constitution, and WHOQOL-BREF-Taiwan version questionnaires. We considered the association between constitutions and quality of life of HIV-infected MSM patients. . The project accepted 203 HIV-infected MSM participants. The three most common pathological constitutions were Yang deficiency 15.5%, yin deficiency 13.1%, and qi deficiency 11.2%. The study determined scores for various quality of life domains: psychological (13.44 ± 2.27), social relationship (13.81 ± 2.80), physiological (14.43 ± 2.41), and environmental (14.78 ± 2.21). The TCM constitution is strongly correlated with the quality of life. Excess constitution had the worst quality of life. Comparing the infected time over one year with the time of <0-2 weeks, the adjusted odds ratios (AOR) were determined for abnormal CD4 and CD4/CD8 ratio (OR: odds ratio: 0.03, 0.07, respectively, < 0.001). Compared with the Gentleness constitution, there is a significant difference between the Deficiency and Excess constitution in sleep status and negative mood by multiple regression analysis ( < 0.001).
The Excess constitutions was correlated with worse quality of life. Even if the immune system was restored, the psychosocial domain, sleep status, and negative mood were not improved.
本研究探讨了与HIV感染的男男性接触者生活质量低下相关的病理体质，为临床治疗提供参考。
采用横断面研究设计，使用结构化问卷收集数据，包括患者的基本数据、CD4、CD4/CD8比值、王琦体质以及世界卫生组织生活质量简表台湾版问卷。我们考虑了体质与HIV感染的男男性接触者生活质量之间的关联。该项目纳入了203名HIV感染的男男性接触者参与者。三种最常见的病理体质为阳虚（15.5%）、阴虚（13.1%）和气虚（11.2%）。该研究确定了各个生活质量领域的得分：心理（13.44±2.27）、社会关系（13.81±2.80）、生理（14.43±2.41）和环境（14.78±2.21）。中医体质与生活质量密切相关。实证体质的生活质量最差。将感染时间超过一年与<0 - 2周的时间进行比较，确定了CD4和CD4/CD8比值异常的调整优势比（AOR）（OR：优势比：分别为0.03、0.07，<0.001）。通过多元回归分析，与平和质相比，虚证体质和实证体质在睡眠状况和负面情绪方面存在显著差异（<0.001）。
实证体质与较差的生活质量相关。即使免疫系统恢复，心理社会领域、睡眠状况和负面情绪也未得到改善。
