Li Shirui, Wang Kang, Wang Zeyu, Zhang Wenjie, Liu Zenglin, Cheng Yugang, Zhu Jiankang, Zhong Mingwei, Hu Sanyuan, Zhang Yun
Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Front Chem. 2023 Jan 9;10:1113546. doi: 10.3389/fchem.2022.1113546. eCollection 2022.
Bioluminescence imaging is a non-invasive technology used to visualize physiological processes in animals and is useful for studying the dynamics of metabolic syndrome. Metabolic syndrome is a broad spectrum of diseases which are rapidly increasing in prevalence, and is closely associated with obesity, type 2 diabetes, nonalcoholic fatty liver disease, and circadian rhythm disorder. To better serve metabolic syndrome research, researchers have established a variety of animal models expressing luciferase, while also committing to finding more suitable luciferase promoters and developing more efficient luciferase-luciferin systems. In this review, we systematically summarize the applications of different models for bioluminescence imaging in the study of metabolic syndrome.
生物发光成像技术是一种用于可视化动物体内生理过程的非侵入性技术，在代谢综合征动力学研究中具有重要作用。代谢综合征是一类发病率迅速上升的广泛疾病，与肥胖、2型糖尿病、非酒精性脂肪性肝病和昼夜节律紊乱密切相关。为了更好地服务于代谢综合征研究，研究人员建立了多种表达荧光素酶的动物模型，同时致力于寻找更合适的荧光素酶启动子并开发更高效的荧光素酶-荧光素系统。在这篇综述中，我们系统地总结了不同生物发光成像模型在代谢综合征研究中的应用。
