Department of Oral Medicine and Periodontology, School of Medicine, University of Split, Split, Croatia.
Department of Dental Medicine, University Hospital Centre Split, Split, Croatia.
J Periodontol. 2023 Jun;94(6):765-776. doi: 10.1002/JPER.22-0351. Epub 2023 Mar 8.
Kidney transplant recipients (KTRs) represent a vulnerable group of patients who develop a number of comorbidities. Severe periodontitis (SP) is associated with the most common chronic systemic diseases including kidney diseases. The objective of this study was to explore the risk factors for SP in KTRs.
In this study, KTRs were divided into those with or without periodontitis and in relation to the severity of periodontitis. A comprehensive medical and periodontal examination was performed and evaluated. Multivariate logistic regression was performed to examine possible risk factors for SP among KTRs.
A total of 100 KTRs were included in the analysis, of which 87% had periodontitis. Significant predictors of periodontitis were older age (OR = 1.07, 95% CI [1.01, 1.13], p = 0.016) and lower skeletal muscle mass (OR = 0.88, 95% CI [0.78, 0.99], p = 0.035). When examining periodontitis severity, predictors of SP (n = 21, 24%) were increased levels of uric acid (OR = 1.01, 95% CI [1.00, 1.02], p = 0.022) and dental plaque (OR = 1.04, 95% CI [1.01, 1.07], p = 0.013). In the subset analysis that included only KTRs with measured advanced glycation end products (AGE) (n = 47), 34% (n = 16) had SP. The predictors of SP were AGE (OR = 3.89, 95% CI [1.28, 11.82], p = 0.017) and dental plaque (OR = 1.07, 95% CI [1.01, 1.13], p = 0.028).
KTRs with SP had significantly higher uric acid levels and AGE, which may contribute to the systemic health status of this patient population.
肾移植受者（KTR）是一组易患多种合并症的脆弱患者群体。重度牙周炎（SP）与包括肾脏疾病在内的最常见慢性系统性疾病相关。本研究的目的是探讨 KTR 中 SP 的危险因素。
本研究将 KTR 分为有或无牙周炎以及牙周炎严重程度。进行了全面的医学和牙周检查并进行了评估。进行了多变量逻辑回归分析，以检查 KTR 中 SP 的可能危险因素。
共纳入 100 例 KTR 进行分析，其中 87%有牙周炎。牙周炎的显著预测因素是年龄较大（OR=1.07，95%CI[1.01，1.13]，p=0.016）和骨骼肌质量较低（OR=0.88，95%CI[0.78，0.99]，p=0.035）。在检查牙周炎严重程度时，SP 的预测因素（n=21，24%）是尿酸水平升高（OR=1.01，95%CI[1.00，1.02]，p=0.022）和牙菌斑（OR=1.04，95%CI[1.01，1.07]，p=0.013）。在仅包括有测量的晚期糖基化终产物（AGE）的 KTR 的亚组分析中（n=47），有 34%（n=16）患有 SP。SP 的预测因素是 AGE（OR=3.89，95%CI[1.28，11.82]，p=0.017）和牙菌斑（OR=1.07，95%CI[1.01，1.13]，p=0.028）。
患有 SP 的 KTR 的尿酸水平和 AGE 显著升高，这可能导致该患者人群的全身健康状况恶化。
