Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Department of Orthopedic Surgery, The Second Hospital University of South China, Hengyang, China.
PLoS One. 2023 Jan 26;18(1):e0280989. doi: 10.1371/journal.pone.0280989. eCollection 2023.
Ferroptosis is a cell death form that has been reported to be involved in the progression of gastric cancer (GC). However, the underlying mechanism of ferroptosis in GC still needs to be further explored. This study conducted a survey regarding the biological functions of ferroptosis-related gene AKR1C2 in GC. Multiple bioinformatic platforms were applied to indicate that the expression level of AKR1C2 was downregulated in GC tissues, which displayed good prognostic value. Clinical statistics proved that AKR1C2 expression was correlated with several tumor characteristics of GC patients, such as characteristics of N-stage tumor or residual tumor. Additionally, LinkedOmics was employed to explore the co-expression network and molecular pathways of AKR1C2 in GC. Eventually, AKR1C2 was found to be involved in several immune-related signatures, such as immunostimulators, immunoinhibitors, chemokines and chemokine receptors. To sum up, these results may provide a novel insight into the significance and biological functions of ferroptosis-related gene AKR1C2 in GC tumorigenesis.
铁死亡是一种已被报道与胃癌（GC）进展有关的细胞死亡形式。然而，铁死亡在 GC 中的潜在机制仍需要进一步探索。本研究对铁死亡相关基因 AKR1C2 在 GC 中的生物学功能进行了调查。应用多个生物信息学平台表明，AKR1C2 在 GC 组织中的表达水平下调，具有良好的预后价值。临床统计证明，AKR1C2 的表达与 GC 患者的几种肿瘤特征相关，如 N 期肿瘤或残留肿瘤的特征。此外，还利用 LinkedOmics 探索了 AKR1C2 在 GC 中的共表达网络和分子途径。最终发现 AKR1C2 参与了几个免疫相关的特征，如免疫刺激物、免疫抑制剂、趋化因子和趋化因子受体。总之，这些结果可能为铁死亡相关基因 AKR1C2 在 GC 肿瘤发生中的意义和生物学功能提供新的见解。
