Pu Feifei, Chen Fengxia, Zhang Zhicai, Shi Deyao, Zhong Binlong, Lv Xiao, Tucker Andrew Blake, Fan Jiaming, Li Alexander J, Qin Kevin, Hu Daniel, Chen Connie, Wang Hao, He Fang, Ni Na, Huang Linjuan, Liu Qing, Wagstaff William, Luu Hue H, Haydon Rex C, Shen Le, He Tong-Chuan, Liu Jianxiang, Shao Zengwu
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China.
Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, PR China.
Genes Dis. 2020 Dec 4;9(2):347-357. doi: 10.1016/j.gendis.2020.11.019. eCollection 2022 Mar.
The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis, but some patient's show apoptosis escape and chemotherapy resistance. Therefore, other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment. Ferroptosis is a newly discovered iron-dependent, non-apoptotic type of cell death that is highly negatively correlated with cancer development. Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.
癌症治疗主要包括手术切除，并辅以放疗和化疗。化疗药物通过干扰肿瘤生长和诱导癌细胞死亡来发挥作用。抗肿瘤药物旨在诱导细胞凋亡，但一些患者会出现凋亡逃逸和化疗耐药。因此，在癌症治疗中，能够克服肿瘤细胞耐药性的其他细胞死亡形式很重要。铁死亡是一种新发现的铁依赖性、非凋亡性细胞死亡，与癌症发展高度负相关。铁死亡主要由铁依赖性脂质活性氧的异常增加和氧化还原稳态失衡引起。本文综述了铁死亡在癌症中的研究进展和调控机制，并探讨了其在癌症诊断和治疗中的潜在临床应用。
