Department of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.
KU Diabetes Institute, The University of Kansas Medical Center, Kansas City, Kansas, United States.
J Appl Physiol (1985). 2023 Mar 1;134(3):685-691. doi: 10.1152/japplphysiol.00711.2022. Epub 2023 Jan 26.
Exercise is a physiological stress that disrupts tissue and cellular homeostasis while enhancing systemic metabolic energy demand mainly through the increased workload of skeletal muscle. Although the extensive focus has been on skeletal muscle adaptations to exercise, the liver senses these disruptions in metabolic energy homeostasis and responds to provide the required substrates to sustain increased demand. Hepatic metabolic flexibility is an energetically costly process that requires continuous mitochondrial production of the cellular currency ATP. To do so, the liver must maintain a healthy functioning mitochondrial pool, attained through well-regulated and dynamic processes. Intriguingly, some of these responses are sex-dependent. This mini-review examines the hepatic mitochondrial adaptations to exercise with a focus on sexual dimorphism.
运动是一种生理应激，它破坏组织和细胞的内稳态，同时通过增加骨骼肌的工作量来增强全身代谢能量需求。尽管人们广泛关注骨骼肌对运动的适应，但肝脏会感知到代谢能量稳态的这些破坏，并做出响应以提供维持增加需求所需的底物。肝脏的代谢灵活性是一个能量消耗大的过程，需要线粒体不断产生细胞货币 ATP。为此，肝脏必须通过调节良好且动态的过程来维持健康的线粒体池。有趣的是，其中一些反应是性别依赖性的。这篇迷你综述探讨了肝脏线粒体对运动的适应，重点是性别二态性。
