Shanyhin A, Babienko V, Vatan M, Rozhnova A, Strakhov Ye
1Odessa National Medical University, Ukraine.
2Odessa I.I. Mechnikov National University, Ukraine.
Georgian Med News. 2022 Nov(332):93-98.
Vitamin D deficiency is being challenged by the European and global pandemic. Exploring the role of other components in the system of regulation of lipid metabolism, their interrelationships with other systems, without a doubt, building a broader understanding of the pathogenesis of dyslipidemia and promoting new methods of correction and prevention. Impaired lipid metabolism may be accompanied by accumulation of inactive forms of vitamin D due to supra-excess catabolic processes, as well as enzymatic impairment due to a decrease in hydroxylase activity in the liver infiltrated with fat. Vitamin D deficiency can be considered as an independent factor in the risk of accumulation of adipose tissue due to the significant number of vitamin D receptors in the adipose tissue, and take part in lipogenesis, lipogenesis adipogenesis. In the course of the study, 928 residents of the southern region of Ukraine aged from 19 to 82 were examined. The study took place during the year, which made it possible to evaluate the fluctuations of the 25(OH)D level in different months with different duration of insolation. It was established that 33.6% of the examinees had a deficiency of 25(OH)D in blood serum, 33% had an insufficiency, and a sufficient level was noted in 33.4% of the examinees. Cultivation of level 25(OH)D was observed in fallow season. We also carried out a correlation analysis between 25(OH)D and lipid profiles in different seasons. Given data about the need for active follow-up of lipid metabolism and vitamin-D-deficiency in the population with further development and implementation of the system of prevention.
维生素D缺乏正受到欧洲乃至全球疫情的挑战。毫无疑问，探索脂质代谢调节系统中其他成分的作用及其与其他系统的相互关系，有助于更全面地理解血脂异常的发病机制，并推动新的纠正和预防方法。脂质代谢受损可能伴随着维生素D非活性形式的积累，这是由于分解代谢过程过度，以及脂肪浸润的肝脏中羟化酶活性降低导致的酶功能障碍。由于脂肪组织中存在大量维生素D受体，维生素D缺乏可被视为脂肪组织积累风险的一个独立因素，并且参与脂肪生成、脂肪形成。在这项研究中，对928名年龄在19至82岁之间的乌克兰南部地区居民进行了检查。该研究持续了一年，这使得评估不同月份日照时长不同时25(OH)D水平的波动成为可能。结果发现，33.6%的受检者血清中25(OH)D缺乏，33%的受检者不足，33.4%的受检者水平充足。在休耕季节观察到25(OH)D水平的变化。我们还对不同季节的25(OH)D与血脂谱进行了相关性分析。鉴于这些数据，有必要在人群中积极跟踪脂质代谢和维生素D缺乏情况，并进一步完善和实施预防体系。
