乌克兰的维生素D缺乏症：一项多中心横断面研究。

Vitamin D deficiency in Ukraine: A multicentre cross-sectional study.

作者信息

Shatylo Sofiia, Bogomaz Volodymyr, Babych Oleksii

机构信息

Department of Internal Medicine, Faculty of Dentistry, Bogomolets National Medical University, 9 Volodymyr Vynnychenko Str., 04053 Kyiv, Ukraine.

Department оf Modern Technologies оf Medical Diagnostics and Treatment, Bogomolets National Medical University, 34 Beresteiskyi Ave., 03057 Kyiv, Ukraine.

出版信息

Glob Epidemiol. 2024 Oct 10;8:100170. doi: 10.1016/j.gloepi.2024.100170. eCollection 2024 Dec.

DOI:10.1016/j.gloepi.2024.100170

PMID:39483738

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525160/

Abstract

BACKGROUND

Available epidemiological data on vitamin D status in the Ukrainian population are limited.

OBJECTIVE

The aim of this study is to investigate the prevalence of vitamin D deficiency in Ukraine.

METHODS

This multicentre cross-sectional study included a total of 11,462 participants: 1530 children with a median age 10 years, (IQR 6-14) and 56.21 % of them were female; 9932 adults with a median age of 36 years (IQR 26-48) and 78.72 % of them were female. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured once by chemiluminescent immunoassay (UniCel DxI 800 Access Immunoassay System, Beckman Coulter Inc., USA) in the period of January-December 2021 in Kyiv and Kyiv Oblast. The cut-offs were: vitamin D deficiency, <50 nmol/L; moderate deficiency, 25-<50 nmol/L; severe deficiency, <25 nmol/L; vitamin D insufficiency, 50-<75 nmol/L; vitamin D sufficiency, 75-<250 nmol/L; optimal concentration, 75-<125 nmol/L; increased levels, 125-<250 nmol/L; and toxicity, ≥250 nmol/L.

RESULTS

The median 25(OH)D level was 65.4 nmol/L (IQR 49.5-85.6) among all participants, severe vitamin D deficiency was recorded in 2.9 % of participants (95 % CI: 2.6-3.2), moderate deficiency in 23 % (95 % CI: 22-24), and vitamin D insufficiency in 37 % (95 % CI: 36-38).Prevalence of vitamin D deficiency in group 1-17 years was 23.5 % (95 % CI: 21-26). We did not find vitamin D deficiency in children aged 1-2 years; however toxic levels were recorded in 4.2 % of the children in this age group (95 % CI: 1.4-9.6). Among the adults (≥18 years old), prevalence of vitamin D deficiency was 26 % (95 % CI: 25-27).

CONCLUSION

Vitamin D deficiency and insufficiency are common in Ukraine.

摘要

背景

关于乌克兰人群维生素D状况的现有流行病学数据有限。

目的

本研究旨在调查乌克兰维生素D缺乏症的患病率。

方法

这项多中心横断面研究共纳入11462名参与者：1530名儿童，中位年龄10岁（四分位间距6 - 14岁），其中56.21%为女性；9932名成年人，中位年龄36岁（四分位间距26 - 48岁），其中78.72%为女性。于2021年1月至12月期间在基辅和基辅州通过化学发光免疫分析法（美国贝克曼库尔特公司的UniCel DxI 800 Access免疫分析系统）一次性测量血清25 - 羟基维生素D（25(OH)D）水平。临界值如下：维生素D缺乏，<50 nmol/L；中度缺乏，25 - <50 nmol/L；重度缺乏，<25 nmol/L；维生素D不足，50 - <75 nmol/L；维生素D充足，75 - <250 nmol/L；最佳浓度，75 - <125 nmol/L；水平升高，125 - <250 nmol/L；毒性，≥250 nmol/L。

结果

所有参与者的25(OH)D中位水平为65.4 nmol/L（四分位间距49.5 - 85.6），2.9%的参与者存在重度维生素D缺乏（95%置信区间：2.6 - 3.2），23%存在中度缺乏（95%置信区间：22 - 24），37%存在维生素D不足（95%置信区间：36 - 38）。1 - 17岁组维生素D缺乏的患病率为23.5%（95%置信区间：21 - 26）。我们未在1 - 2岁儿童中发现维生素D缺乏；然而，该年龄组4.2%的儿童记录到有毒水平（95%置信区间：1.4 - 9.6）。在成年人（≥18岁）中，维生素D缺乏的患病率为26%（95%置信区间：25 - 27）。