Shatylo Sofiia, Bogomaz Volodymyr, Babych Oleksii
Department of Internal Medicine, Faculty of Dentistry, Bogomolets National Medical University, 9 Volodymyr Vynnychenko Str., 04053 Kyiv, Ukraine.
Department оf Modern Technologies оf Medical Diagnostics and Treatment, Bogomolets National Medical University, 34 Beresteiskyi Ave., 03057 Kyiv, Ukraine.
Glob Epidemiol. 2024 Oct 10;8:100170. doi: 10.1016/j.gloepi.2024.100170. eCollection 2024 Dec.
Available epidemiological data on vitamin D status in the Ukrainian population are limited.
The aim of this study is to investigate the prevalence of vitamin D deficiency in Ukraine.
This multicentre cross-sectional study included a total of 11,462 participants: 1530 children with a median age 10 years, (IQR 6-14) and 56.21 % of them were female; 9932 adults with a median age of 36 years (IQR 26-48) and 78.72 % of them were female. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured once by chemiluminescent immunoassay (UniCel DxI 800 Access Immunoassay System, Beckman Coulter Inc., USA) in the period of January-December 2021 in Kyiv and Kyiv Oblast. The cut-offs were: vitamin D deficiency, <50 nmol/L; moderate deficiency, 25-<50 nmol/L; severe deficiency, <25 nmol/L; vitamin D insufficiency, 50-<75 nmol/L; vitamin D sufficiency, 75-<250 nmol/L; optimal concentration, 75-<125 nmol/L; increased levels, 125-<250 nmol/L; and toxicity, ≥250 nmol/L.
The median 25(OH)D level was 65.4 nmol/L (IQR 49.5-85.6) among all participants, severe vitamin D deficiency was recorded in 2.9 % of participants (95 % CI: 2.6-3.2), moderate deficiency in 23 % (95 % CI: 22-24), and vitamin D insufficiency in 37 % (95 % CI: 36-38).Prevalence of vitamin D deficiency in group 1-17 years was 23.5 % (95 % CI: 21-26). We did not find vitamin D deficiency in children aged 1-2 years; however toxic levels were recorded in 4.2 % of the children in this age group (95 % CI: 1.4-9.6). Among the adults (≥18 years old), prevalence of vitamin D deficiency was 26 % (95 % CI: 25-27).
Vitamin D deficiency and insufficiency are common in Ukraine.
关于乌克兰人群维生素D状况的现有流行病学数据有限。
本研究旨在调查乌克兰维生素D缺乏症的患病率。
这项多中心横断面研究共纳入11462名参与者：1530名儿童，中位年龄10岁（四分位间距6 - 14岁），其中56.21%为女性；9932名成年人，中位年龄36岁（四分位间距26 - 48岁），其中78.72%为女性。于2021年1月至12月期间在基辅和基辅州通过化学发光免疫分析法（美国贝克曼库尔特公司的UniCel DxI 800 Access免疫分析系统）一次性测量血清25 - 羟基维生素D（25(OH)D）水平。临界值如下：维生素D缺乏，<50 nmol/L；中度缺乏，25 - <50 nmol/L；重度缺乏，<25 nmol/L；维生素D不足，50 - <75 nmol/L；维生素D充足，75 - <250 nmol/L；最佳浓度，75 - <125 nmol/L；水平升高，125 - <250 nmol/L；毒性，≥250 nmol/L。
所有参与者的25(OH)D中位水平为65.4 nmol/L（四分位间距49.5 - 85.6），2.9%的参与者存在重度维生素D缺乏（95%置信区间：2.6 - 3.2），23%存在中度缺乏（95%置信区间：22 - 24），37%存在维生素D不足（95%置信区间：36 - 38）。1 - 17岁组维生素D缺乏的患病率为23.5%（95%置信区间：21 - 26）。我们未在1 - 2岁儿童中发现维生素D缺乏；然而，该年龄组4.2%的儿童记录到有毒水平（95%置信区间：1.4 - 9.6）。在成年人（≥18岁）中，维生素D缺乏的患病率为26%（95%置信区间：25 - 27）。
维生素D缺乏和不足在乌克兰很常见。
