Musk A W, Ryan G F, Perera D M, D'Souza B P, Hockey R L, Hobbs M S
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Nedlands, WA.
Med J Aust. 1987 Nov 2;147(9):423-7.
From a cohort of all 5760 male and 4979 female patients who were admitted to WA hospitals and were discharged with a diagnosis of asthma between 1976 and 1980, 265 deaths in men and 189 deaths in women were identified by the end of 1982. The standardized mortality ratio (SMR) for all causes of death for this cohort was 1.6 for men (P less than 0.001) and 1.7 for women (P less than 0.001). Both sexes showed a significant increase in deaths that were attributable to asthma (SMR, 57.9), chronic airflow obstruction (SMR, 9.3) and ischaemic heart disease (SMR, 1.3). The excess death rates for asthma were observed in all age groups, but those for chronic airflow obstruction and ischaemic heart disease were present in older age groups only. These findings indicate that asthma remains a potentially fatal disease in the Australian community. The excess mortality ratios for chronic airflow obstruction that were observed in patients who were admitted to hospital with asthma also suggest that asthma may result in irreversible airflow obstruction.
在1976年至1980年间，西澳大利亚州各医院收治的并被诊断为哮喘后出院的所有患者中，共有5760名男性和4979名女性。到1982年底，已确认男性中有265人死亡，女性中有189人死亡。该队列所有死因的标准化死亡率（SMR），男性为1.6（P＜0.001），女性为1.7（P＜0.001）。两性因哮喘（SMR为57.9）、慢性气流阻塞（SMR为9.3）和缺血性心脏病（SMR为1.3）导致的死亡均显著增加。各年龄组均观察到哮喘的超额死亡率，但慢性气流阻塞和缺血性心脏病的超额死亡率仅出现在老年组。这些发现表明，哮喘在澳大利亚社区仍然是一种潜在的致命疾病。在因哮喘入院的患者中观察到的慢性气流阻塞的超额死亡率也表明，哮喘可能导致不可逆的气流阻塞。
