2013-2018 年英国癫痫的发病率和患病率：英国初级保健数据的回顾性队列研究。

The incidence and prevalence of epilepsy in the United Kingdom 2013-2018: A retrospective cohort study of UK primary care data.

机构信息

Former employee of Epilepsy Action, Yeadon, Leeds, United Kingdom.

Homerton University Hospital Foundation Trust, Homerton Row, London E9 6SR, United Kingdom; DCEE, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom.

出版信息

Seizure. 2023 Feb;105:37-42. doi: 10.1016/j.seizure.2023.01.003. Epub 2023 Jan 5.

DOI:10.1016/j.seizure.2023.01.003

PMID:36702018

Abstract

PURPOSE

The aim of this study was to update overall incidence and prevalence calculations for epilepsy of the United Kingdom (UK) and its constituent nations (England, Northern Ireland, Scotland, and Wales).

METHODS

We used data from primary care practices contributing to the Clinical Practice Research Datalink (CRPD), based on the electronic health records of 14 million patients, representing approximately 20% of the population. CPRD contains data from two different health record systems: the Vision clinical system (CPRD GOLD database) and the EMIS Web® clinical system (CPRD Aurum database). We calculated incidence and prevalence rates with 95% confidence intervals (CIs). Data were stratified by age, gender, deprivation, country (England, Scotland, Wales and Northern Ireland) and region (England only).

RESULTS

In the UK, the estimated overall point prevalence for epilepsy was 9.37 per 1000 persons / year (95% CI 9.34-9.40) and the overall estimated incidence rate was 42.68 per 100,000 person-years (95% 42.18-43.18) using the CPRD GOLD database. In England, the estimated incidence (37.41 (95% CI 36.96-37.83)) and prevalence (8.85 (95% CI 8.83-8.87)) was lower (combined databases) compared to figures for Scotland (incidence 47.76 (95% CI 46.15-49.42)); prevalence 10.13 (95% CI 10.06-10.20)) (CPRD GOLD only), Wales (incidence 54.84 (95% CI 52.79-56.95); prevalence 11.40 (95% CI 11.31-11.49)) (CPRD GOLD only) and Northern Ireland (incidence 46.18 (95% CI 43.13-49.90); prevalence 12.08 (95% CI 11.93-12.23))(combined databases). Prevalence and incidence were higher in more deprived regions.

CONCLUSION

The prevalence and incidence of epilepsy in the UK is broadly in line with other high income countries, showing the usual pattern of high incidence in the young and the old, with a nadir in middle age. The prevalence of epilepsy has fallen slightly since 2011. There is significant geographical variation (between countries and between regions), and a suggestion of a relationship between deprivation and epilepsy which needs further investigation.

摘要

目的

本研究旨在更新英国（英国）及其组成国家（英格兰、北爱尔兰、苏格兰和威尔士）的癫痫整体发病率和患病率计算。

方法

我们使用了来自参与临床实践研究数据链接（CRPD）的初级保健实践的数据，该数据基于 1400 万患者的电子健康记录，代表了约 20%的人口。CRPD 包含来自两个不同健康记录系统的数据：Vision 临床系统（CPRD GOLD 数据库）和 EMIS Web®临床系统（CPRD Aurum 数据库）。我们使用 95%置信区间（CI）计算发病率和患病率。数据按年龄、性别、贫困程度、国家（英格兰、苏格兰、威尔士和北爱尔兰）和地区（仅英格兰）进行分层。

结果

在英国，使用 CPRD GOLD 数据库，癫痫的估计总体点患病率为每 1000 人/年 9.37 例（95%CI 9.34-9.40），总体估计发病率为每 100,000 人年 42.68 例（95%42.18-43.18）。在英格兰，与苏格兰（发病率 37.41（95%CI 36.96-37.83））和患病率（8.85（95%CI 8.83-8.87））相比，发病率（37.41（95%CI 36.96-37.83））和患病率（8.85（95%CI 8.83-8.87））较低（联合数据库）（发病率 47.76（95%CI 46.15-49.42））；患病率 10.13（95%CI 10.06-10.20））（CPRD GOLD 仅）、威尔士（发病率 54.84（95%CI 52.79-56.95）；患病率 11.40（95%CI 11.31-11.49））（CPRD GOLD 仅）和北爱尔兰（发病率 46.18（95%CI 43.13-49.90）；患病率 12.08（95%CI 11.93-12.23））（联合数据库）。在较贫困的地区，患病率和发病率较高。