Kaokhieo Jirapimon, Tretriluxana Jarugool, Chaiyawat Pakaratee, Siripornpanich Vorasith, Permpoonputtana Kannika, Tretriluxana Suradej, Nanbancha Ampika
Motor Control and Neural Plasticity Laboratory, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand.
Motor Control and Neural Plasticity Laboratory, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand.
Brain Res. 2023 Apr 1;1804:148258. doi: 10.1016/j.brainres.2023.148258. Epub 2023 Jan 23.
To investigate the feasibility of a combined high-frequency rTMS (HF-rTMS) with action observation and execution (AOE) on social interaction and communication in children with Autistic Spectrum Disorder (ASD).
Fifteen children underwent 10 sessions of 5-Hz HF-rTMS on the right inferior frontal gyrus combined with AOE. An experimental group received the real HF-rTMS while the control group received the sham one. For the AOE protocol, they were instructed to watch and imitate a video showing the procedure, including reaching and grasping tasks, gustatory tasks, and facial expressions. Their behavioural outcomes were evaluated using the Vineland Adaptive Behaviour Scale (VABS) and electroencephalograms (EEGs) recorded at three time points: baseline, immediately after each treatment, and at the 1-week follow-up after the 10th treatment.
There were increased VABS subitem scores in the experimental group, including the receptive, expressive, domestic, and community scores but no such increase was observed in the control group. For the EEG, the beta rhythm at C3 and C4 increased in the experimental group. Additionally, positive correlations were observed between changes in the scores for the expressive subitem and changes in the beta rhythm on the C4 electrode at baseline and immediately after treatment in the experimental group. The control group showed no significant differences in any items for both observation and imitation times.
Ten sessions of HF-rTMS combined with AOE could improve both the subitems of communication and daily living skills domain in children aged 7-12 years with ASD. Although it is still inconclusive, this behavioural improvement may be partly attributable to increased cortical activity, as evidenced by beta rhythms.
探讨高频重复经颅磁刺激（HF-rTMS）联合动作观察与执行（AOE）对孤独症谱系障碍（ASD）儿童社交互动和交流能力的可行性。
15名儿童在右侧额下回接受10次5赫兹的高频重复经颅磁刺激，并联合动作观察与执行训练。实验组接受真正的高频重复经颅磁刺激，而对照组接受假刺激。对于动作观察与执行训练方案，指导他们观看并模仿一段展示相关程序的视频，包括伸手抓取任务、味觉任务和面部表情。使用文兰适应行为量表（VABS）评估他们的行为结果，并在三个时间点记录脑电图（EEG）：基线、每次治疗后即刻以及第10次治疗后的1周随访。
实验组的文兰适应行为量表子项得分有所提高，包括接受、表达、家庭和社区得分，而对照组未观察到此类增加。对于脑电图，实验组中C3和C4处的β节律增加。此外，在实验组中，表达性子项得分的变化与基线和治疗后即刻C4电极上β节律的变化之间存在正相关。对照组在观察和模仿时间的任何项目上均未显示出显著差异。
10次高频重复经颅磁刺激联合动作观察与执行训练可改善7至12岁孤独症谱系障碍儿童的沟通和日常生活技能领域的子项。尽管仍无定论，但这种行为改善可能部分归因于皮质活动的增加，如β节律所示。
