人类染色体中Alu家族重复序列的非随机分布。
Non-random distribution of Alu-family repeats in human chromosomes.
作者信息
Filatov L V, Mamayeva S E, Tomilin N V
机构信息
Institute of Cytology, Academy of Sciences of USSR, Leningrad.
出版信息
Mol Biol Rep. 1987;12(2):117-22. doi: 10.1007/BF00368879.
A phage lambda recombinant clone containing at least 8 Alu-family repeats (AFRs) has been isolated from a human genomic library, and DNA from the phage was used as a probe for in situ hybridization on G-banded human metaphase chromosomes of healthy donors and leukemic patients. Some chromosome bands show prominent clusters of silver grains in all individuals examined: 1p34, 1q23, 2q21-22, 10p14, 11p14, 10q21 and 11q14. The data suggest non-random distribution of AFRs in the human genome.
从人类基因组文库中分离出了一个含有至少8个Alu家族重复序列（AFR）的λ噬菌体重组克隆，并将该噬菌体的DNA用作探针，对健康供体和白血病患者的G带人类中期染色体进行原位杂交。在所有检测的个体中，一些染色体带显示出明显的银粒簇：1p34、1q23、2q21 - 22、10p14、11p14、10q21和11q14。数据表明AFR在人类基因组中呈非随机分布。
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