Geng Chuanying, Yang Guangzhong, Zhou Huixing, Wang Huijuan, Li Yanchen, Leng Yun, Zhang Zhiyao, Jian Yuan, Chen Wenming
Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Clin Exp Med. 2023 Oct;23(6):2593-2600. doi: 10.1007/s10238-023-01002-7. Epub 2023 Jan 26.
The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to evaluate basic activities of daily life, but few studies have evaluated its prognostic value in MM. We retrospectively enrolled patients with newly diagnosed MM and analyzed the association between the BI and the survival of newly diagnosed MM patients. We totally analyzed 538 patients and found that median overall survival (OS) and progression-free survival (PFS) were significantly shorter in the low BI (≤ 85) group compared with the high BI (> 85) group. Univariate Cox proportional hazards regression analysis showed that the low BI was associated with shorter OS and PFS. It was also confirmed that the low BI was poor prognostic factor for OS and PFS in multivariable analyses. In the propensity score matching analysis, patients with low BI also had shorter OS and PFS. Our study suggested that the low BI was a poor prognostic factor for patients with newly diagnosed MM.
日常生活的基本活动可能会影响多发性骨髓瘤（MM）患者的预后，巴氏指数（BI）是目前评估日常生活基本活动最广泛使用的工具，但很少有研究评估其在MM中的预后价值。我们回顾性纳入新诊断的MM患者，并分析BI与新诊断MM患者生存之间的关联。我们共分析了538例患者，发现低BI（≤85）组的中位总生存期（OS）和无进展生存期（PFS）明显短于高BI（>85）组。单因素Cox比例风险回归分析显示，低BI与较短的OS和PFS相关。多变量分析也证实，低BI是OS和PFS的不良预后因素。在倾向评分匹配分析中，低BI患者的OS和PFS也较短。我们的研究表明，低BI是新诊断MM患者的不良预后因素。
