Department of Nutrition and Dietetics, Idaho State University, Pocatello, ID, USA.
Nutr Health. 2023 Dec;29(4):621-635. doi: 10.1177/02601060231153428. Epub 2023 Jan 26.
Anticancer therapies are associated with significant adverse side effects and few treatments that alleviate symptoms exist. Branched-chain amino acids (BCAAs) have been investigated as an intervention for reducing anticancer therapy side effects, although a review of the literature results has yet to be published. The current review summarizes evidence surrounding this topic and suggests both support and caution in using BCAAs as a treatment for patients receiving anticancer therapies. In this review, two literature searches were completed. Google Scholar, PubMed, EBSCOhost, and Cochrane databases were searched using the terms "branched-chain amino acids and cancer" and "BCAA and cancer." Two bodies of evidence emerged: One supporting beneficial effects and the other showing adverse outcomes of BCAA supplementation in patients with cancer. Evidence of benefit was a decrease in malnourishment and unintentional weight loss during and after chemotherapy. Potential harms included the idea cancer cells may utilize BCAAs as a source of energy for growth. Supplementation of BCAAs in individuals with cancer should be implemented cautiously. Those who are severely malnourished due to anticancer therapy may benefit the most. BCAA supplementation may also be provided once cancer has been destroyed from the individual's body to aid with recovery.
抗癌疗法会引起严重的不良反应，并且缓解症状的治疗方法也很少。支链氨基酸（BCAAs）已被研究作为减轻抗癌疗法副作用的干预措施，尽管尚未发表对该文献的综述结果。 目前的综述总结了围绕这一主题的证据，并建议在使用 BCAA 作为接受抗癌疗法的患者的治疗方法时，既提供支持，也提供谨慎。 在本次综述中，进行了两次文献检索。使用“支链氨基酸和癌症”和“BCAA 和癌症”这两个术语，在 Google Scholar、PubMed、EBSCOhost 和 Cochrane 数据库中进行了搜索。出现了两种证据：一种支持有益效果，另一种显示癌症患者补充 BCAA 的不良结果。有益的证据是在化疗期间和之后减少营养不良和非自愿体重减轻。潜在的危害包括癌细胞可能将 BCAA 用作生长的能量来源。 应谨慎在癌症患者中补充 BCAA。由于抗癌疗法而严重营养不良的人可能受益最大。在个体体内的癌症被摧毁后，也可以提供 BCAA 补充以帮助恢复。
